Korean J Hematol 1999; 34(3):

Published online September 30, 1999

© The Korean Society of Hematology

재발된 급성 혼합형 백혈병 환아에서의 제대혈 조혈모세포 이식후 성공적인 생착

이영호, 조남철, 제구화, 한훈, 한진영, 김재석, 김효진, 조빈, 김학기

동아대학교 의과대학 동아암센터 조혈세포이식 프로그램,
가톨릭대학교 의과대학 소아과학교실

Successful Sibling Cord Blood Stem Cell Transplantation for Relapsed Acute Mixed lineage leukemic

Young Ho Lee, Nam Cheol Cho, Ku Hwa Je, Hoon Han, Jin Yeong Han, Jae Seok Kim, Hyo Jin Kim, Bin Cho, Hack Ki Kim

Hematopoietic Stem Cell Transplantation Program, Dong, A Cancer Center, A University College of Medicine, Pusan
Department of Pediatrics, Catholic University Medical College, Seoul, Korea

Abstract

We experienced a successful transplantation using HLA-matched sibling cord blood In a 5 years old girl with relapsed acute mixed lineage leukemia.
The patient was diagnosed as acute lymphoblastic leukemia (ALL) in August, 1995, and received anticancer chemotherapy until October, 1997. She maintained complete remission until January, 1998, when relapsed as mixed lineage leukemia with the phenotype of T cell ALL with coexpression of myeloid antigens. After achieving second complete remission by reinduction chemotherapy, we planned a cord blood transplant for our patient, whose mother was in the third trimester of pregnancy at the time of relapse.
The volume of collected cord blood was 100 mL and fortunately, histocompatibility test disclosed complete matching with the patient. The cord blood was cryopreserved following depletion of red cells with 3% gelatin. The thawed cord blood consisting of 3.6×107/㎏ of total nucleated cells and 3.3×105/㎏ of CD34+ cells, was infused to the patient following myeloablative chemotherapy. The absolute neutrophil count exceeded 500/㎕ on day +37 and platelet count (untransfused) 20,000/㎕ on day +114. She suffered from 2 episodes of sepsis and CMV pneumonia during her clinical course but recovered completely without complication and discharged with good condition on day +116.

Keywords Cord blood, Stem cell transplantation, Acute leukemia

Article

Korean J Hematol 1999; 34(3): 471-476

Published online September 30, 1999

Copyright © The Korean Society of Hematology.

재발된 급성 혼합형 백혈병 환아에서의 제대혈 조혈모세포 이식후 성공적인 생착

이영호, 조남철, 제구화, 한훈, 한진영, 김재석, 김효진, 조빈, 김학기

동아대학교 의과대학 동아암센터 조혈세포이식 프로그램,
가톨릭대학교 의과대학 소아과학교실

Successful Sibling Cord Blood Stem Cell Transplantation for Relapsed Acute Mixed lineage leukemic

Young Ho Lee, Nam Cheol Cho, Ku Hwa Je, Hoon Han, Jin Yeong Han, Jae Seok Kim, Hyo Jin Kim, Bin Cho, Hack Ki Kim

Hematopoietic Stem Cell Transplantation Program, Dong, A Cancer Center, A University College of Medicine, Pusan
Department of Pediatrics, Catholic University Medical College, Seoul, Korea

Abstract

We experienced a successful transplantation using HLA-matched sibling cord blood In a 5 years old girl with relapsed acute mixed lineage leukemia.
The patient was diagnosed as acute lymphoblastic leukemia (ALL) in August, 1995, and received anticancer chemotherapy until October, 1997. She maintained complete remission until January, 1998, when relapsed as mixed lineage leukemia with the phenotype of T cell ALL with coexpression of myeloid antigens. After achieving second complete remission by reinduction chemotherapy, we planned a cord blood transplant for our patient, whose mother was in the third trimester of pregnancy at the time of relapse.
The volume of collected cord blood was 100 mL and fortunately, histocompatibility test disclosed complete matching with the patient. The cord blood was cryopreserved following depletion of red cells with 3% gelatin. The thawed cord blood consisting of 3.6×107/㎏ of total nucleated cells and 3.3×105/㎏ of CD34+ cells, was infused to the patient following myeloablative chemotherapy. The absolute neutrophil count exceeded 500/㎕ on day +37 and platelet count (untransfused) 20,000/㎕ on day +114. She suffered from 2 episodes of sepsis and CMV pneumonia during her clinical course but recovered completely without complication and discharged with good condition on day +116.

Keywords: Cord blood, Stem cell transplantation, Acute leukemia

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