Korean J Hematol 2011; 46(2):
Published online June 21, 2011
https://doi.org/10.5045/kjh.2011.46.2.135
© The Korean Society of Hematology
1Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
2Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
Correspondence to : Correspondence to Mina Hur, M.D., Ph.D. Department of Laboratory Medicine, Konkuk University School of Medicine, Konkuk University Hospital, 4-12, Hwayang-dong, Gwangjin-gu, Seoul 143-729, Korea. Tel: +82-2-2030-5581, Fax: +82-2-2636-6764, dearmina@hanmail.net
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Variant Burkitt-type translocation, t(8;22)(q24;q11), is very rare in plasma cell myeloma. We report a 51-year-old male patient with plasma cell myeloma, who showed t(8;22) (q24;q11). He suffered from pelvic pain for two months, and showed IgG, lambda type of monoclonal gammopathy (5.14 g/dL; 49.9% of protein). His bone marrow examination showed increased plasma cells (66.9% of all nucleated cells). Plasma cells (74.9% of all nucleated cells) and monoclonal spike (3.38 g/dL; 42.2%) persisted after three cycles of thalidomide and dexamethasone. Cytogenetic analysis showed complex chromosomal abnormalities: 44,XY,-1,t(2;5)(q33;q13),add(8)(q24.1),t(8;22)(q24.1;q11.2),add(10) (p15), der(11)t(1;11)(q21;p11.2),del(12)(p11.2p13),-13,-14,add(14)(q32),der(15)t(1;15)(p2 2;p11.2),-16,add(17)(q11.2),+21,+1-3mar[cp6]/46,XY[19]. To the best of our knowledge, this is the first report on plasma cell myeloma with a variant Burkitt-type t(8;22)(q24;q11) in the Korean patient. A review of 11 such cases in the literature, including the present case, implicated that plasma cell myeloma with t(8;22)(q24;q11) might be related to advanced stage and poor prognosis.
Keywords Plasma cell myeloma, t(8;22)(q24;q11), Variant, Burkitt
Korean J Hematol 2011; 46(2): 135-138
Published online June 21, 2011 https://doi.org/10.5045/kjh.2011.46.2.135
Copyright © The Korean Society of Hematology.
Hanah Kim1, Hee-Won Moon1, Mina Hur1*, Yeo-Min Yun1, Chul-Min Park1, and Mark Hong Lee2
1Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
2Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
Correspondence to: Correspondence to Mina Hur, M.D., Ph.D. Department of Laboratory Medicine, Konkuk University School of Medicine, Konkuk University Hospital, 4-12, Hwayang-dong, Gwangjin-gu, Seoul 143-729, Korea. Tel: +82-2-2030-5581, Fax: +82-2-2636-6764, dearmina@hanmail.net
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Variant Burkitt-type translocation, t(8;22)(q24;q11), is very rare in plasma cell myeloma. We report a 51-year-old male patient with plasma cell myeloma, who showed t(8;22) (q24;q11). He suffered from pelvic pain for two months, and showed IgG, lambda type of monoclonal gammopathy (5.14 g/dL; 49.9% of protein). His bone marrow examination showed increased plasma cells (66.9% of all nucleated cells). Plasma cells (74.9% of all nucleated cells) and monoclonal spike (3.38 g/dL; 42.2%) persisted after three cycles of thalidomide and dexamethasone. Cytogenetic analysis showed complex chromosomal abnormalities: 44,XY,-1,t(2;5)(q33;q13),add(8)(q24.1),t(8;22)(q24.1;q11.2),add(10) (p15), der(11)t(1;11)(q21;p11.2),del(12)(p11.2p13),-13,-14,add(14)(q32),der(15)t(1;15)(p2 2;p11.2),-16,add(17)(q11.2),+21,+1-3mar[cp6]/46,XY[19]. To the best of our knowledge, this is the first report on plasma cell myeloma with a variant Burkitt-type t(8;22)(q24;q11) in the Korean patient. A review of 11 such cases in the literature, including the present case, implicated that plasma cell myeloma with t(8;22)(q24;q11) might be related to advanced stage and poor prognosis.
Keywords: Plasma cell myeloma, t(8,22)(q24,q11), Variant, Burkitt
Bone marrow aspiration smear showing increased plasma cells (Wright-Giemsa stain, ×1,000).
Karyogram of follow-up bone marrow cells by Giemsa banding technique. 44,XY,-1,t(2;5) (q33;q13),add(8)(q24.1),t(8;22)(q24.1;q11.2),add(10)(p15),der(11)t(1;11)(q21;p11.2),del(12)(p11.2p13),-13,-14,add(14)(q32),der(15)t(1;15)(p22;p11.2),-16,add(17)(q11.2),+21,+1-3mar[cp6].
Table 1 . Summary of 11 cases with plasma cell myeloma and t(8;22)(q24;q11)..
a)according to the Durie and Salmon staging system, b)survival duration from diagnosis, c)alive..
Except the present case, the others show the karyotype at initial diagnosis..
Abbreviations: y, years; m, months; BJP, Bence Jones protein; F, female; M, male; NR, not reported; BM-PC, plasma cells in bone marrow..
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Bone marrow aspiration smear showing increased plasma cells (Wright-Giemsa stain, ×1,000).
|@|~(^,^)~|@|Karyogram of follow-up bone marrow cells by Giemsa banding technique. 44,XY,-1,t(2;5) (q33;q13),add(8)(q24.1),t(8;22)(q24.1;q11.2),add(10)(p15),der(11)t(1;11)(q21;p11.2),del(12)(p11.2p13),-13,-14,add(14)(q32),der(15)t(1;15)(p22;p11.2),-16,add(17)(q11.2),+21,+1-3mar[cp6].