Korean J Hematol 1999; 34(2):
Published online June 30, 1999
© The Korean Society of Hematology
이제중, 정익주, 김형준, 박무림, 신동현, 변정래, 권상용, 양덕환, 김찬종, 국훈, 황태주, 김종필, 양동욱
전남대학교 의과대학 내과학교실,
전남대학교 의과대학 소아과학교실,
전남대학교 의과대학 임상병리학교실
Background: After a zealous advocates of granulocyte transfusion therapy (GTX) in the 1970s and early 1980s, the use of GTX has diminished strikingly because of the several problems of GTX and the introduction of new antimicrobial agents and recombinant hematopoietic growth factors. Recently, GTX offers renewed interest because several investigators reported the trans-granulocyte-colony stimulating factor(G-CSF).
Method: To evaluate the safety and efficacy of GTX, thirteen patients with neutropenia-related infections at Chonnam University Hospital from March 1997 to February 1998 were treated with dexamethasone or G-CSF-stimulated granulocyte transfusions apheresed from normal donor.
Result: Patients received a mean number of 2.4 transfusions (range,1-7)and a mean dose of 5.5×1010 granulocytes (range, 0.2-19.6). Six patients (46.2%) had favorable responses. Favorable responses occurred among patients with more fungal infection than vacterial infection (71.4 vs 28.6%, P<0.05) and more increment of absolute neutrophil count at 1 hour after (P<0.05). Adverse reactions of GTX were pulmonary edema in 2 patient (15.4%) and transient hypoxia in 1 patient(7.7%). One patient(7.7%) with pulmonary edema died of severe pulmonary reaction. Two of 20 donors received by G-CSF complaind of mild myalgia and bone pain.
Conclusion: G-CSF or dexamethasone-stimulated GTXs were well tolerated and may be clinically beneficial for neutropenia-related infection, particulary in fungal infection, that is refractory to antimicrobial therapy.
Keywords Granulocyte transfusion therapy, Neutropenia, Infection, G-CSF
Korean J Hematol 1999; 34(2): 326-333
Published online June 30, 1999
Copyright © The Korean Society of Hematology.
이제중, 정익주, 김형준, 박무림, 신동현, 변정래, 권상용, 양덕환, 김찬종, 국훈, 황태주, 김종필, 양동욱
전남대학교 의과대학 내과학교실,
전남대학교 의과대학 소아과학교실,
전남대학교 의과대학 임상병리학교실
Je Jung Lee, Ik Joo Chung, Hyeoung Joon Kim, Moo Rim Park, Dong Hyeon Shin, Jeong Rae Byun, Sang Yong Kwon, Duc Hwan Yang, Chan Jong Kim, Hoon Kook, Tai Ju Hwang, Jong Phil Kim, Dong Wook Ryang
Department of Internal Medicine, Pediatrics, Clinical Pathology, Chonnam University Medical School, Kwangju, Korea
Background: After a zealous advocates of granulocyte transfusion therapy (GTX) in the 1970s and early 1980s, the use of GTX has diminished strikingly because of the several problems of GTX and the introduction of new antimicrobial agents and recombinant hematopoietic growth factors. Recently, GTX offers renewed interest because several investigators reported the trans-granulocyte-colony stimulating factor(G-CSF).
Method: To evaluate the safety and efficacy of GTX, thirteen patients with neutropenia-related infections at Chonnam University Hospital from March 1997 to February 1998 were treated with dexamethasone or G-CSF-stimulated granulocyte transfusions apheresed from normal donor.
Result: Patients received a mean number of 2.4 transfusions (range,1-7)and a mean dose of 5.5×1010 granulocytes (range, 0.2-19.6). Six patients (46.2%) had favorable responses. Favorable responses occurred among patients with more fungal infection than vacterial infection (71.4 vs 28.6%, P<0.05) and more increment of absolute neutrophil count at 1 hour after (P<0.05). Adverse reactions of GTX were pulmonary edema in 2 patient (15.4%) and transient hypoxia in 1 patient(7.7%). One patient(7.7%) with pulmonary edema died of severe pulmonary reaction. Two of 20 donors received by G-CSF complaind of mild myalgia and bone pain.
Conclusion: G-CSF or dexamethasone-stimulated GTXs were well tolerated and may be clinically beneficial for neutropenia-related infection, particulary in fungal infection, that is refractory to antimicrobial therapy.
Keywords: Granulocyte transfusion therapy, Neutropenia, Infection, G-CSF
Jae Hyuk Choi, Gu Lee, Hyun Ah Oh, Hee Jung Kwang, Jae Lyun Lee, Kyung Hee Lee, Myung Soo Hyun, Hun Mo Ryu
Korean J Hematol 2002; 37(1): 17-23Hong Bin Kim, Sang Won Park, Ui Seok Kim, Jin Wook Kim, Dong Hyeon Shin, Myoung Don Oh, Seon Yang Park, Byung Kook Kim, Kang Won Choe
Korean J Hematol 1999; 34(3): 359-365Alireza Sadeghi, Somayeh Sadeghi, Mohammad Saleh Peikar, Maryam Yazdi, Mehran Sharifi, Safie Ghafel, Farzin Khorvash, Behrooz Ataei, Mohammad Reza Safavi, Elahe Nasri
Blood Res 2023; 58(2): 91-98