Korean J Hematol 2004; 39(3):
Published online September 30, 2004
© The Korean Society of Hematology
장문주, 류경희, 정소영, 오도연, 강명서
포천중문의과대학교 분당차병원 내과,
포천중문의과대학교 분당차병원 진단검사의학과
Hairy cell leukemia-variant (HCL-variant) is a rare B-cell disorder of hairy cell leukemia cases. The main features are splenomegaly, lymphocytosis and cytopenias without monocytopenia. Diagnosis is based on the distinctive hairy cell morphology and immunophenotype. Cells from hairy cell leukemia (HCL) and HCL-variant have a distinct immunophenotype which is of a mature but not terminally differentiated activated B-cell. We experienced a case of HCL- variant in a 50-year-old man with marked splenomegaly and skin eruptions. Peripheral blood smear showed abnormal lymphoid cells with cytoplasmic projections. The bone marrow was easily aspirated and showed hypercellularity and diffuse interstitial infiltration of hairy cells. Tartrate-resistant acid phosphatase (TRAP) reactivity was negative in the hairy cells. Immunophenotyping results of lymphoid cells were CD2 (-), CD3 (-), CD5 (-), CD7 (-), CD10 (-), CD19 (++), CD20 (+++), sKappa (-), sLambda (+), CD23 (-), CD25 (-), FMC7 (+) and CD103 (++).
Keywords Hairy cell leukemia, Variant, Splenomegaly
Korean J Hematol 2004; 39(3): 167-171
Published online September 30, 2004
Copyright © The Korean Society of Hematology.
장문주, 류경희, 정소영, 오도연, 강명서
포천중문의과대학교 분당차병원 내과,
포천중문의과대학교 분당차병원 진단검사의학과
Moon Ju Jang, Kueng Hee Rhyu, So Young Chong, Doyeun Oh, Myung Seo Kang
Department of Internal Medicine, Laboratory Medicine, Bundang CHA Hospital, Pochon CHA University College of Medicine, Sungnam, Korea
Hairy cell leukemia-variant (HCL-variant) is a rare B-cell disorder of hairy cell leukemia cases. The main features are splenomegaly, lymphocytosis and cytopenias without monocytopenia. Diagnosis is based on the distinctive hairy cell morphology and immunophenotype. Cells from hairy cell leukemia (HCL) and HCL-variant have a distinct immunophenotype which is of a mature but not terminally differentiated activated B-cell. We experienced a case of HCL- variant in a 50-year-old man with marked splenomegaly and skin eruptions. Peripheral blood smear showed abnormal lymphoid cells with cytoplasmic projections. The bone marrow was easily aspirated and showed hypercellularity and diffuse interstitial infiltration of hairy cells. Tartrate-resistant acid phosphatase (TRAP) reactivity was negative in the hairy cells. Immunophenotyping results of lymphoid cells were CD2 (-), CD3 (-), CD5 (-), CD7 (-), CD10 (-), CD19 (++), CD20 (+++), sKappa (-), sLambda (+), CD23 (-), CD25 (-), FMC7 (+) and CD103 (++).
Keywords: Hairy cell leukemia, Variant, Splenomegaly
Young Rok Do, Yunsuk Choi, Mi Hwa Heo, Jin Seok Kim, Jae-ho Yoon, Je-Hwan Lee, Joon Seong Park, Sang Kyun Sohn, Sung Hyun Kim, Sungnam Lim, Joo Seop Chung, Deog-Yeon Jo, Hyeon Seok Eom, Hawk Kim, So Yeon Jeon, Jong-Ho Won, Hee Jeong Lee, Jung Won Shin, Jun-Ho Jang, Sung-Soo Yoon
Blood Res 2022; 57(3): 207-215Hebatallah Adel Sedky, Soha Raouf Youssef, Doaa Ahmad Gamal, Heba Fawzy Houssein, Walaa Ali Elsalakawy
Blood Res 2020; 55(4): 253-261Hanah Kim, Hee-Won Moon, Mina Hur, Yeo-Min Yun, Chul-Min Park, and Mark Hong Lee
Korean J Hematol 2011; 46(2): 135-138