Korean J Hematol 1993; 28(2):
Published online June 30, 1993
© The Korean Society of Hematology
만성골수성백혈병 만성기 환자의 동종골수이식 후 발생한 급성백혈병 1례
오흥범, 박성섭, 김병국, 조현찬, 조한익, 김상인
서울의대 임상병리과학교실,
서울의대 내과학교실
한림의대 임상병리학교실
A Case of Blastic Relapse after Allogeneic Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase
Allogeneic bone marrow transplantation(BMT) is the only curative therapy for chronic myelogenous leukemia(CML). But a proportion of patients with chronic phase CML
receiving BMT show hematological relapses, of which are usually chronic phase, but rarely acute phase. We report a 23-year-old male patient who was diagnosed as chronic
phase of CML and had BMT from his HLA-matched sister, and relapsed into blast crisis 131 days after transplantation without the preceding chronic phase of CML. The
possible explanations for this unusual event are undetected acute phase before BMT, undetected preceding chronic phase and blastic proliferation of residual leukemic cells.
Keywords Chronic myelogenous leukemia; Blast crisis; Bone marrow transplantation;
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Korean J Hematol 1993; 28(2): 413-419
Published online June 30, 1993
Copyright © The Korean Society of Hematology.
만성골수성백혈병 만성기 환자의 동종골수이식 후 발생한 급성백혈병 1례
오흥범, 박성섭, 김병국, 조현찬, 조한익, 김상인
서울의대 임상병리과학교실,
서울의대 내과학교실
한림의대 임상병리학교실
A Case of Blastic Relapse after Allogeneic Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase
Heung Bum Oh, Sung Sup Park, Byoung Kook Kim, Hyoun Chan Cho, Han Ik Cho, Sang In Kim
Department of Clinical Pathology, Internal Medicine, Seoul National University College of Medicine
Department of Internal Medicine, Hallym University College of Medicine
Abstract
Allogeneic bone marrow transplantation(BMT) is the only curative therapy for chronic myelogenous leukemia(CML). But a proportion of patients with chronic phase CML
receiving BMT show hematological relapses, of which are usually chronic phase, but rarely acute phase. We report a 23-year-old male patient who was diagnosed as chronic
phase of CML and had BMT from his HLA-matched sister, and relapsed into blast crisis 131 days after transplantation without the preceding chronic phase of CML. The
possible explanations for this unusual event are undetected acute phase before BMT, undetected preceding chronic phase and blastic proliferation of residual leukemic cells.
Keywords: Chronic myelogenous leukemia, Blast crisis, Bone marrow transplantation,
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