Korean J Hematol 1993; 28(2):
Published online June 30, 1993
© The Korean Society of Hematology
파종성 혈관내 응고증을 위한 혈장 섬유소원 분해산물 측정의 진단적 효율성 관찰
송경순, 최종락, 김혜선, 이미경
연세의대 임상병리과학교실
Diagnostic Efficacy of Fibrinogen Degradation Product(FgDP) Assay in Disseminated Intravascular Coagulation
Background: The presence of fibrinogen/fibrin degradation product in plasma is one of the important parameters for the diagnosis of disseminated intravascular coagulation(DIC). By using newly developed assay specific for fibrinogen degradation product(FgDP) or fibrin degradation product(FbDP), accelerated fibrinogenolysis or
fibrinolysis can be assessed separately.
Methods: We have observed diagnostic efficacy of FgDP in 70 patients referred for supected DIC and 20 healthy controls. FgDP was measured with a recently developed
sandwich-type ELISA (Fibrinostika, Organon Teknika) in plasma samples.
Results: Based on DIC criteria, the patients were classified into two categories : DIC(n=16) and no DIC(n=54). Sensitivity, specificity and overall percentage accuracy of FgDP assay were 93.8%, 87.0%, 88.6%, respectively, at the diagnostic level of 580 ng/ml,
which was upper limit of 95% range in controls.
Conclusion: Compared with D-dimer assay, FgDP assay seems to be more specific but less sensitive and these results suggest that simultaneous measurements of both
D-dimer and FgDP can be clinically useful for the diagnosis of hyperfibrinolytic states in DIC.
Keywords Fibrinogen degradation product; Disseminated intravascular coagulation; Fibrinolysis;
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Korean J Hematol 1993; 28(2): 351-356
Published online June 30, 1993
Copyright © The Korean Society of Hematology.
파종성 혈관내 응고증을 위한 혈장 섬유소원 분해산물 측정의 진단적 효율성 관찰
송경순, 최종락, 김혜선, 이미경
연세의대 임상병리과학교실
Diagnostic Efficacy of Fibrinogen Degradation Product(FgDP) Assay in Disseminated Intravascular Coagulation
Kyung Soon Song, Chong Rak Choi, Hae Sun Kim, Mi Kyeong Lee
Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea
Abstract
Background: The presence of fibrinogen/fibrin degradation product in plasma is one of the important parameters for the diagnosis of disseminated intravascular coagulation(DIC). By using newly developed assay specific for fibrinogen degradation product(FgDP) or fibrin degradation product(FbDP), accelerated fibrinogenolysis or
fibrinolysis can be assessed separately.
Methods: We have observed diagnostic efficacy of FgDP in 70 patients referred for supected DIC and 20 healthy controls. FgDP was measured with a recently developed
sandwich-type ELISA (Fibrinostika, Organon Teknika) in plasma samples.
Results: Based on DIC criteria, the patients were classified into two categories : DIC(n=16) and no DIC(n=54). Sensitivity, specificity and overall percentage accuracy of FgDP assay were 93.8%, 87.0%, 88.6%, respectively, at the diagnostic level of 580 ng/ml,
which was upper limit of 95% range in controls.
Conclusion: Compared with D-dimer assay, FgDP assay seems to be more specific but less sensitive and these results suggest that simultaneous measurements of both
D-dimer and FgDP can be clinically useful for the diagnosis of hyperfibrinolytic states in DIC.
Keywords: Fibrinogen degradation product, Disseminated intravascular coagulation, Fibrinolysis,
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