Korean J Hematol 1993; 28(2):
Published online June 30, 1993
© The Korean Society of Hematology
Von Willebrand병 분류를 위한 Von Willebrand 인자 검색
손영우, 계경채, 신현춘, 이홍복, 오도연, 박선양, 김병국, 김노경
한국보훈병원 내과,
서울의대 내과,
순천향의대 내과
Laboratory Assessment of von Willebrand Factor for Classification of von Willebrand Disease
Background: Von Willebrand Disease(vWD) appears to be the most commonly diagnosed hereditary bleeding disorder. We set up laboratory methods for the correct diagnosis of vWD.
Methods: We diagnosed 12 patients who had von Willebrand factor(vWF) antigen levels below 60% as vWD. Adding 2 family members, 14 patients were studied.
Results: Bleeding times were prolonged over 4 minutes in 4 patients. Ristocetin-induced platelet aggregation data were compatible with vWD in 3 patients. vWF antigen levels were 0-57% and vWF ristocetin cofactor activities were 0-74%.
Multimer analysis of vWF revealed that one family 1 had the type I vWD.
Conclusion: We expect increasing numbers of vWD patients will be detected with correct subclassification in the future.
Keywords Von Willebrand Disease; von Willebrand factor; Ristocetin-induced Platelet Aggregation; von Willebrand factor Antigen; Ristocetin Cofactor activity; Multimer Analysis of von Willebrand factor;
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Korean J Hematol 1993; 28(2): 345-350
Published online June 30, 1993
Copyright © The Korean Society of Hematology.
Von Willebrand병 분류를 위한 Von Willebrand 인자 검색
손영우, 계경채, 신현춘, 이홍복, 오도연, 박선양, 김병국, 김노경
한국보훈병원 내과,
서울의대 내과,
순천향의대 내과
Laboratory Assessment of von Willebrand Factor for Classification of von Willebrand Disease
Young Woo Son, Kyung Chae Kye, Hyun Chun Shin, Hong Bock Lee, Do Yeun Oh, Seonyang Park, Byeong Kook Kim, Noe Kyeong Kim
Department of Internal Medicine, Korea Veterans Hospital
Seoul National Uiversity College of Medicine
Soonchunhyang University College of Medicine
Abstract
Background: Von Willebrand Disease(vWD) appears to be the most commonly diagnosed hereditary bleeding disorder. We set up laboratory methods for the correct diagnosis of vWD.
Methods: We diagnosed 12 patients who had von Willebrand factor(vWF) antigen levels below 60% as vWD. Adding 2 family members, 14 patients were studied.
Results: Bleeding times were prolonged over 4 minutes in 4 patients. Ristocetin-induced platelet aggregation data were compatible with vWD in 3 patients. vWF antigen levels were 0-57% and vWF ristocetin cofactor activities were 0-74%.
Multimer analysis of vWF revealed that one family 1 had the type I vWD.
Conclusion: We expect increasing numbers of vWD patients will be detected with correct subclassification in the future.
Keywords: Von Willebrand Disease, von Willebrand factor, Ristocetin-induced Platelet Aggregation, von Willebrand factor Antigen, Ristocetin Cofactor activity, Multimer Analysis of von Willebrand factor,
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