Case Report

Korean J Hematol 2006; 41(2):

Published online June 30, 2006

https://doi.org/10.5045/kjh.2006.41.2.105

© The Korean Society of Hematology

급성신부전에서 저용량의 All-trans Retinoic Acid로 관해 유도에 성공한 급성전골수성백혈병 1예

박혜원, 최주현, 이단비, 구동회, 구자은, 김세희, 이제환, 이정희, 이규형

울산대학교 의과대학 서울아산병원 내과학교실

Low-dose All-trans Retinoic Acid for Remission Induction of Acute Promyelocytic Leukemia in Acute Renal Failure

Hye Won Park, Ju Hyun Choi, Dan bi Lee, Dong Hoe Koo, Ja Eun Koo, Sai Hui Kim, Je Hwan Lee, Jung Hee Lee, Kyoo Hyung Lee

Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

Abstract

All-trans retinoic acid (ATRA) is the standard induction treatment for acute promyelocytic leukemia (APL). Renal involvement sometimes necessitates a dose reduction or discontinuation of induction therapy for hematological malignancies. We report here on a case of APL that achieved complete remission with low-dose ATRA treatment despite the patient's acute renal failure. A 42-year-old woman presented with a 2 month history of ecchymosis and she was subsequently diagnosed with APL. During induction treatment with ATRA and idarubicin, oliguria developed and her azotemia rapidly progressed. Because of the progressive deterioration in her general condition, the patient was transferred to the intensive care unit. We started renal replacement therapy for her acute renal failure and we discontinued ATRA treatment. Her urine output started to increase, and there was an improvement in the patient's general condition. We resumed low-dose ATRA treatment. She achieved complete remission after 52 days of treatment.

Keywords All-trans retinoic acid, Renal insufficiency, Acute promyelocytic leukemia

Article

Case Report

Korean J Hematol 2006; 41(2): 105-109

Published online June 30, 2006 https://doi.org/10.5045/kjh.2006.41.2.105

Copyright © The Korean Society of Hematology.

급성신부전에서 저용량의 All-trans Retinoic Acid로 관해 유도에 성공한 급성전골수성백혈병 1예

박혜원, 최주현, 이단비, 구동회, 구자은, 김세희, 이제환, 이정희, 이규형

울산대학교 의과대학 서울아산병원 내과학교실

Low-dose All-trans Retinoic Acid for Remission Induction of Acute Promyelocytic Leukemia in Acute Renal Failure

Hye Won Park, Ju Hyun Choi, Dan bi Lee, Dong Hoe Koo, Ja Eun Koo, Sai Hui Kim, Je Hwan Lee, Jung Hee Lee, Kyoo Hyung Lee

Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

Abstract

All-trans retinoic acid (ATRA) is the standard induction treatment for acute promyelocytic leukemia (APL). Renal involvement sometimes necessitates a dose reduction or discontinuation of induction therapy for hematological malignancies. We report here on a case of APL that achieved complete remission with low-dose ATRA treatment despite the patient's acute renal failure. A 42-year-old woman presented with a 2 month history of ecchymosis and she was subsequently diagnosed with APL. During induction treatment with ATRA and idarubicin, oliguria developed and her azotemia rapidly progressed. Because of the progressive deterioration in her general condition, the patient was transferred to the intensive care unit. We started renal replacement therapy for her acute renal failure and we discontinued ATRA treatment. Her urine output started to increase, and there was an improvement in the patient's general condition. We resumed low-dose ATRA treatment. She achieved complete remission after 52 days of treatment.

Keywords: All-trans retinoic acid, Renal insufficiency, Acute promyelocytic leukemia

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