Korean J Hematol 2006; 41(2):
Published online June 30, 2006
https://doi.org/10.5045/kjh.2006.41.2.105
© The Korean Society of Hematology
박혜원, 최주현, 이단비, 구동회, 구자은, 김세희, 이제환, 이정희, 이규형
울산대학교 의과대학 서울아산병원 내과학교실
All-trans retinoic acid (ATRA) is the standard induction treatment for acute promyelocytic leukemia (APL). Renal involvement sometimes necessitates a dose reduction or discontinuation of induction therapy for hematological malignancies. We report here on a case of APL that achieved complete remission with low-dose ATRA treatment despite the patient's acute renal failure. A 42-year-old woman presented with a 2 month history of ecchymosis and she was subsequently diagnosed with APL. During induction treatment with ATRA and idarubicin, oliguria developed and her azotemia rapidly progressed. Because of the progressive deterioration in her general condition, the patient was transferred to the intensive care unit. We started renal replacement therapy for her acute renal failure and we discontinued ATRA treatment. Her urine output started to increase, and there was an improvement in the patient's general condition. We resumed low-dose ATRA treatment. She achieved complete remission after 52 days of treatment.
Keywords All-trans retinoic acid, Renal insufficiency, Acute promyelocytic leukemia
Korean J Hematol 2006; 41(2): 105-109
Published online June 30, 2006 https://doi.org/10.5045/kjh.2006.41.2.105
Copyright © The Korean Society of Hematology.
박혜원, 최주현, 이단비, 구동회, 구자은, 김세희, 이제환, 이정희, 이규형
울산대학교 의과대학 서울아산병원 내과학교실
Hye Won Park, Ju Hyun Choi, Dan bi Lee, Dong Hoe Koo, Ja Eun Koo, Sai Hui Kim, Je Hwan Lee, Jung Hee Lee, Kyoo Hyung Lee
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
All-trans retinoic acid (ATRA) is the standard induction treatment for acute promyelocytic leukemia (APL). Renal involvement sometimes necessitates a dose reduction or discontinuation of induction therapy for hematological malignancies. We report here on a case of APL that achieved complete remission with low-dose ATRA treatment despite the patient's acute renal failure. A 42-year-old woman presented with a 2 month history of ecchymosis and she was subsequently diagnosed with APL. During induction treatment with ATRA and idarubicin, oliguria developed and her azotemia rapidly progressed. Because of the progressive deterioration in her general condition, the patient was transferred to the intensive care unit. We started renal replacement therapy for her acute renal failure and we discontinued ATRA treatment. Her urine output started to increase, and there was an improvement in the patient's general condition. We resumed low-dose ATRA treatment. She achieved complete remission after 52 days of treatment.
Keywords: All-trans retinoic acid, Renal insufficiency, Acute promyelocytic leukemia
Yoon Seok Koh, Seok Lee, Yoo Jin Kim, Jusang Kim, Seok In Hong, Yoon Hee Park, Hee Je Kim, Dong Wook Kim, Jong Wook Lee, Woo Sung Min, Chun Choo Kim
Korean J Hematol 2003; 38(3): 191-194Byeong Hun Kim, Byeong Duk Kim, Sung Mok Kim, Eun Jung Lee, Kyeong Hee Lee, Myung Soo Hyun
Korean J Hematol 1998; 33(1): 117-123Seok Lee, Yoo Hong Min, So Young Chong, Jee Sook Hahn, Yun Woong Ko
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