Korean J Hematol 1998; 33(1):
Published online March 31, 1998
© The Korean Society of Hematology
Retinoic Acid 증후군 2례
김병훈, 김병덕, 김성목, 이은정, 이경희, 현명수
영남대학교 의과대학 내과학교실
Two Cases of Retinoic Acid Syndrome
Recent studies showed that all-trans retinoic acid induces complete remission in many patients with acute promyelocytic leukemia(84%). Unlikely cytotoxic drugs, it does not induce rapid cell lysis that initiates the disseminated intravascular coagulation(DIC) and often improves DIC within the first several days after treatment. Furthermore it does not induce bone marrow suppression with its consequent pancytopenia and increased risk for infection. Retinoic acid syndrome characterized by fever, respiratory distress, radiographic pulmonary infiltrates, pleural effusions, episodic hypotension, and weight gain have developed in approximately one-fourth of the patients.
We experienced two cases of retinoic acid syndrome in 49 and 35-year-old females who were diagnosed as acute
promyelocytic leukemia and received all-trans retinoic acid 45mg/㎡/day per oral. In both patients, retinoic acid syndrome was recovered by early treatment with dexamethasone 10mg intravenously every 12 hours for 4 or 5 days.
Keywords Acute promyelocytic leukemia; All-trans retinoic acid; Retinoic acid syndrome;
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Korean J Hematol 1998; 33(1): 117-123
Published online March 31, 1998
Copyright © The Korean Society of Hematology.
Retinoic Acid 증후군 2례
김병훈, 김병덕, 김성목, 이은정, 이경희, 현명수
영남대학교 의과대학 내과학교실
Two Cases of Retinoic Acid Syndrome
Byeong Hun Kim, Byeong Duk Kim, Sung Mok Kim, Eun Jung Lee, Kyeong Hee Lee, Myung Soo Hyun
Department of Internal Medicine, College of Medicine, Yeungnam University, Taegu, Korea
Abstract
Recent studies showed that all-trans retinoic acid induces complete remission in many patients with acute promyelocytic leukemia(84%). Unlikely cytotoxic drugs, it does not induce rapid cell lysis that initiates the disseminated intravascular coagulation(DIC) and often improves DIC within the first several days after treatment. Furthermore it does not induce bone marrow suppression with its consequent pancytopenia and increased risk for infection. Retinoic acid syndrome characterized by fever, respiratory distress, radiographic pulmonary infiltrates, pleural effusions, episodic hypotension, and weight gain have developed in approximately one-fourth of the patients.
We experienced two cases of retinoic acid syndrome in 49 and 35-year-old females who were diagnosed as acute
promyelocytic leukemia and received all-trans retinoic acid 45mg/㎡/day per oral. In both patients, retinoic acid syndrome was recovered by early treatment with dexamethasone 10mg intravenously every 12 hours for 4 or 5 days.
Keywords: Acute promyelocytic leukemia, All-trans retinoic acid, Retinoic acid syndrome,
