Korean J Hematol 2004; 39(3):
Published online September 30, 2004
© The Korean Society of Hematology
홍석인, 송명준, 김연성, 김태훈, 조석구, 이동건, 이혜경
가톨릭대학교 의과대학 혈액종양내과,
가톨릭대학교 의과대학 감염내과,
가톨릭대학교 의과대학 임상병리과
Cryptococcus neoformans commonly causes opportunistic infection in other immunocompromised patients as well as in AIDS. Among cryptococcosis, cryptococcal meningitis is a relatively frequent manifestation and causes serious morbidity and mortality. It needs urgent diagnosis and effective antifungal therapy. We experienced cryptococcal meningitis in a 25-year- old female patient with autoimmune hemolytic anemia. She was admitted because of autoimmune hemolytic crisis. Her anemic symptoms were controlled by steroid and red cell transfusions. However, she was suddenly readmitted with decreased mentality. Seven days later, she was diagnosed as cryptococcal meningitis and cryptococcemia resulting from culture studies of CSF and blood. Since treated with amphotericin B and flucytosine and maintained with prudent fluconazole therapy, her symptoms and general conditions were improved. We report an unusual case of cryptococcal meningitis developed in a patient with autoimmune hemolytic anemia in spite of short-term steroid therapy.
Keywords Meningitis, Cryptococcal meningitis, Anemia, Hemolytic, Autoimmune, Steroids
Korean J Hematol 2004; 39(3): 191-195
Published online September 30, 2004
Copyright © The Korean Society of Hematology.
홍석인, 송명준, 김연성, 김태훈, 조석구, 이동건, 이혜경
가톨릭대학교 의과대학 혈액종양내과,
가톨릭대학교 의과대학 감염내과,
가톨릭대학교 의과대학 임상병리과
Seok In Hong, Myoung Joon Song, Yeon Seong Kim, Tae Hun Kim, Seok Goo Cho, Dong Gun Lee, Hae Kyung Lee
Division of Hematology, Infectious Disease, Clinical Laboratories, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea
Cryptococcus neoformans commonly causes opportunistic infection in other immunocompromised patients as well as in AIDS. Among cryptococcosis, cryptococcal meningitis is a relatively frequent manifestation and causes serious morbidity and mortality. It needs urgent diagnosis and effective antifungal therapy. We experienced cryptococcal meningitis in a 25-year- old female patient with autoimmune hemolytic anemia. She was admitted because of autoimmune hemolytic crisis. Her anemic symptoms were controlled by steroid and red cell transfusions. However, she was suddenly readmitted with decreased mentality. Seven days later, she was diagnosed as cryptococcal meningitis and cryptococcemia resulting from culture studies of CSF and blood. Since treated with amphotericin B and flucytosine and maintained with prudent fluconazole therapy, her symptoms and general conditions were improved. We report an unusual case of cryptococcal meningitis developed in a patient with autoimmune hemolytic anemia in spite of short-term steroid therapy.
Keywords: Meningitis, Cryptococcal meningitis, Anemia, Hemolytic, Autoimmune, Steroids
Mi Jeong Lee, Se Won Paik, Hyo Seop Ahn, Chang Yee Hong
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