Korean J Hematol 2004; 39(3):
Published online September 30, 2004
© The Korean Society of Hematology
선종무, 이종석, 이재호, 김진수, 김태민, 김태용, 한세원, 홍용상, 윤성수, 김병국, 박선양
서울대학교 의과대학 내과학교실
We report a case of idiopathic hypereosinophilic syndrome (HES) presenting with deep vein thrombosis and subsequent massive pulmonary embolism. The eosinophilia and thromboembolism improved dramatically with systemic corticosteroid and anticoagulation therapy. However, the early and rapid tapering of corticosteroid, in a state of normal eosinophil count and therapeutic PT level, aggravated thromboembolism. An immediate retrial of corticosteroid made disease improve again. The etiology of HES and the pathogenesis of thrombus formation in HES still remain uncertain but corticosteroid in treatment of HES is yet cardinal and should be maintained for a prolonged period of time.
Keywords Hypereosiniphilic syndrome, Thrombosis, Pulmonary embolism
Korean J Hematol 2004; 39(3): 196-199
Published online September 30, 2004
Copyright © The Korean Society of Hematology.
선종무, 이종석, 이재호, 김진수, 김태민, 김태용, 한세원, 홍용상, 윤성수, 김병국, 박선양
서울대학교 의과대학 내과학교실
Jong Mu Sun, Jong Seok Lee, Jae Ho Lee, Jin Soo Kim, Tae Min Kim, Tae Yong Kim, Sae Won Han, Yong Sang Hong, Sung Soo Yoon, Byoung Kook Kim, Seonyang Park
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
We report a case of idiopathic hypereosinophilic syndrome (HES) presenting with deep vein thrombosis and subsequent massive pulmonary embolism. The eosinophilia and thromboembolism improved dramatically with systemic corticosteroid and anticoagulation therapy. However, the early and rapid tapering of corticosteroid, in a state of normal eosinophil count and therapeutic PT level, aggravated thromboembolism. An immediate retrial of corticosteroid made disease improve again. The etiology of HES and the pathogenesis of thrombus formation in HES still remain uncertain but corticosteroid in treatment of HES is yet cardinal and should be maintained for a prolonged period of time.
Keywords: Hypereosiniphilic syndrome, Thrombosis, Pulmonary embolism
Somayeh Sadeghi, Marjan Golshani, Bahareh Safaeian
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