Korean J Hematol 2001; 36(4):
Published online December 31, 2001
© The Korean Society of Hematology
백승호, 이규택, 이남수, 박성규, 원종호, 홍대식, 박희숙, 조원수
순천향대학교 의과대학 내과학교실,
순천향대학교 의과대학 방사선학교실
Background:Initial treatment of chronic idiopathic thrombocytopenic purpura (ITP) is generally done with corticosteroid. In case of refractory to corticosteroid or dependency, splenectomy seems to be the most effective and definitive
treatment. Partial splenic embolization is an easier procedure with minimal morbidity. We evaluated the efficacy and complications of partial splenic embolization as treatment of chronic ITP refractory to corticosteroid or corticosteroid dependency.
Methods:
Eight patients with chronic ITP and two systemic lupus erythematosus (SLE) patients with immunothrombocytopenia underwent partial splenic embolization. Embolization of 70∼80% of the splenic volume was performed with endocoils or
gelform particles with out anesthesia by selective arterial catheterization and followed up for 4∼50 months. The therapeutic effect of partial splenic embolization was defined on the basis of the platelet count at the last follow-up after partial splenic embolization : complete response, >100,000/㎕, partial response, 100,000∼50,000/㎕ and no response, <50,000/㎕ without medication.
Results:
Partial splenic embolization brought a complete response in six of ten patients, a partial response in three, and no response in one. With a follow-up of 4∼50 months, these responses were maintained in all except three patients. One patient was treated by splenectomy and one by partial splenic embolization again. Tolerance was good in all
patients. Abdominal pain and fever was observed in 8 and 4 patients, respectively. One patient had a left pleural effusion with spontaneous resolution. No serious infection occurred. All patients were discharged within 6 days after partial splenic embolization.
Conclusion:We conclude that partial splenic embolization may be useful and safe procedure and a good alternative to splenectomy in chronic ITP refractory to medical treatment.
Keywords Chronic ITP, Partial splenic embolization
Korean J Hematol 2001; 36(4): 306-310
Published online December 31, 2001
Copyright © The Korean Society of Hematology.
백승호, 이규택, 이남수, 박성규, 원종호, 홍대식, 박희숙, 조원수
순천향대학교 의과대학 내과학교실,
순천향대학교 의과대학 방사선학교실
Seung Ho Baick, Kyu Taek Lee, Nam Su Lee, Sung Kyu Park, Jong Ho Won, Dae Sik Hong, Hee Sook Park, Won Soo Cho
Department of Internal Medicine, Radiology, College of Medicine, Soonchunhyang University, Cheonan, Korea
Background:Initial treatment of chronic idiopathic thrombocytopenic purpura (ITP) is generally done with corticosteroid. In case of refractory to corticosteroid or dependency, splenectomy seems to be the most effective and definitive
treatment. Partial splenic embolization is an easier procedure with minimal morbidity. We evaluated the efficacy and complications of partial splenic embolization as treatment of chronic ITP refractory to corticosteroid or corticosteroid dependency.
Methods:
Eight patients with chronic ITP and two systemic lupus erythematosus (SLE) patients with immunothrombocytopenia underwent partial splenic embolization. Embolization of 70∼80% of the splenic volume was performed with endocoils or
gelform particles with out anesthesia by selective arterial catheterization and followed up for 4∼50 months. The therapeutic effect of partial splenic embolization was defined on the basis of the platelet count at the last follow-up after partial splenic embolization : complete response, >100,000/㎕, partial response, 100,000∼50,000/㎕ and no response, <50,000/㎕ without medication.
Results:
Partial splenic embolization brought a complete response in six of ten patients, a partial response in three, and no response in one. With a follow-up of 4∼50 months, these responses were maintained in all except three patients. One patient was treated by splenectomy and one by partial splenic embolization again. Tolerance was good in all
patients. Abdominal pain and fever was observed in 8 and 4 patients, respectively. One patient had a left pleural effusion with spontaneous resolution. No serious infection occurred. All patients were discharged within 6 days after partial splenic embolization.
Conclusion:We conclude that partial splenic embolization may be useful and safe procedure and a good alternative to splenectomy in chronic ITP refractory to medical treatment.
Keywords: Chronic ITP, Partial splenic embolization
Hend Nabil Ellithy, Sherif Mohamed Yousry, Asmaa Abdel-Aal, Lelian Tawadros, Nouran Momen
Blood Res 2022; 57(3): 229-234