Korean J Hematol 1999; 34(4):
Published online December 31, 1999
© The Korean Society of Hematology
이영진, 소병준, 채권묵, 정병학
원광대학교 의과대학 임상병리학교실,
원광대학교 의과대학 내과학교실
원광대학교 의과대학 일반외과학교실
Parvovirus B19 is a minute, single stranded DNA virus which has been identified as the etiological agent of pure red cell aplasia, erythremia infectiosum (5th disease), hydrops fetalis, or arthralgia. We report a case of pure red cell aplasia caused by parvovirus B19 in renal transplantation. The patient was 39-year-old male who had been diagnosed as chronic renal failure 22 months ago and taken hemodialysis twice a week. He had been taken renal transplantation in October 30th, 1997. But anemia was not improved in first postoperative period. Bone marrow revealed hypocellularity (about 30%) with maturation arrest of erythroid series at pronormoblasts. The pronormoblasts showed very large size, deep blue cytoplasm, cytoplasmic projection, cytoplasmic vacuole and distinct intranuclear eosinophilic inclusions. The parvovirus B19 PCR and anti-parvovirus B19 IgM were positive, but anti-parvovirus B19 IgG was negative. The patient was treated with intravenous immunoglobulin and then
reticulocyte count was increased three weeks later. The follow-up bone marrow revealed normal erythroid precursors and was not found infected giant pronormoblasts seven weeks later.
Keywords Parvovirus B19, Pure red cell aplasia, Renal transplantation
Korean J Hematol 1999; 34(4): 646-650
Published online December 31, 1999
Copyright © The Korean Society of Hematology.
이영진, 소병준, 채권묵, 정병학
원광대학교 의과대학 임상병리학교실,
원광대학교 의과대학 내과학교실
원광대학교 의과대학 일반외과학교실
Young Jin Lee, Byung Jun So, Kwon Mook Chae, Byung Hak Jeong
Department of Clinical Pathology, General Surgery, Internal Medicine, Wonkwang University, School of Medicine, Iksan, Korea
Parvovirus B19 is a minute, single stranded DNA virus which has been identified as the etiological agent of pure red cell aplasia, erythremia infectiosum (5th disease), hydrops fetalis, or arthralgia. We report a case of pure red cell aplasia caused by parvovirus B19 in renal transplantation. The patient was 39-year-old male who had been diagnosed as chronic renal failure 22 months ago and taken hemodialysis twice a week. He had been taken renal transplantation in October 30th, 1997. But anemia was not improved in first postoperative period. Bone marrow revealed hypocellularity (about 30%) with maturation arrest of erythroid series at pronormoblasts. The pronormoblasts showed very large size, deep blue cytoplasm, cytoplasmic projection, cytoplasmic vacuole and distinct intranuclear eosinophilic inclusions. The parvovirus B19 PCR and anti-parvovirus B19 IgM were positive, but anti-parvovirus B19 IgG was negative. The patient was treated with intravenous immunoglobulin and then
reticulocyte count was increased three weeks later. The follow-up bone marrow revealed normal erythroid precursors and was not found infected giant pronormoblasts seven weeks later.
Keywords: Parvovirus B19, Pure red cell aplasia, Renal transplantation
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