Korean J Hematol 1998; 33(2):
Published online June 30, 1998
© The Korean Society of Hematology
말단비대증과 내장역위증을 가진 환자에서 발생한 만성 골수성 백혈병 1례
김현철, 문병식, 곽재용, 임창열
전북대학교 의과대학 내과학교실
A Case of Chronic Myelogenous Leukemia in Patient with Acromegaly and Situs Inversus
Acromegaly is an uncommon disease characterized clinically by enlargement of the aural parts, coarse facial features and visceralomegaly. In most patients, the disorder
arises from a tumor of the anterior pituitary gland that secretes excessive amounts of growth hormone. A few cases have been reported, associated with the development of
leukemia due to increased growth hormone. But, chronic myelogenous leukemia has not been reported in patients with acromegaly.
We report a case of chronic myelogenous leukemia in patients with situs inversus and acromegaly. A 70-year old male patient who was admitted to endocrinology department
because of acromegalic features was referred to the hematology department for the abnormal hematologic findings. LAP score was decreased. Bone marrow aspiration and biopsy revealed chronic myelogenous leukemia. Chest radiographs showed a dextrocardia. Abdominal sonography showed a splenomegaly and transposition of liver and spleen.
Growth hormone level was elevated and pituitary tumor was detected on brain MRI.
Keywords Acromegaly; Chronic myelogenous leukemia; Situs Inversus;
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Korean J Hematol 1998; 33(2): 279-283
Published online June 30, 1998
Copyright © The Korean Society of Hematology.
말단비대증과 내장역위증을 가진 환자에서 발생한 만성 골수성 백혈병 1례
김현철, 문병식, 곽재용, 임창열
전북대학교 의과대학 내과학교실
A Case of Chronic Myelogenous Leukemia in Patient with Acromegaly and Situs Inversus
Hyun Chul Kim, Byung Sik Moon, Jae Yong Kwak, Chang Yeol Yim
Department of Internal Medicine, Chonbuk National University Medical School, Chonju, Korea
Abstract
Acromegaly is an uncommon disease characterized clinically by enlargement of the aural parts, coarse facial features and visceralomegaly. In most patients, the disorder
arises from a tumor of the anterior pituitary gland that secretes excessive amounts of growth hormone. A few cases have been reported, associated with the development of
leukemia due to increased growth hormone. But, chronic myelogenous leukemia has not been reported in patients with acromegaly.
We report a case of chronic myelogenous leukemia in patients with situs inversus and acromegaly. A 70-year old male patient who was admitted to endocrinology department
because of acromegalic features was referred to the hematology department for the abnormal hematologic findings. LAP score was decreased. Bone marrow aspiration and biopsy revealed chronic myelogenous leukemia. Chest radiographs showed a dextrocardia. Abdominal sonography showed a splenomegaly and transposition of liver and spleen.
Growth hormone level was elevated and pituitary tumor was detected on brain MRI.
Keywords: Acromegaly, Chronic myelogenous leukemia, Situs Inversus,
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