Korean J Hematol 1998; 33(2):
Published online June 30, 1998
© The Korean Society of Hematology
혈소판 Glycoprotein Ib/IX 및 Ⅱb/Ⅲa에 특이한 항체를 보인 Rifampin에 의한 혈소판 감소증 1례
강명서, 오도연, 김영철, 강신혜, 김현옥
포천중문의과대학 분당차병원 임상병리과,
포천중문의과대학 분당차병원 내과,
포천중문의과대학 분당차병원 소아과,
연세대학교 의과대학 임상병리과학교실
A Case of Rifampin-Induced Thrombocytopenia Associated with Specific Antibodies for Platelet Glycoprotein Ib/IX and llb/llla
Rifampin is sometimes associated with hematologic complications such as hemolytic anemia or thrombocytopenia. Patients with drug-induced thrombocytopenia develop a
drug dependent antibody that binds to platelets in the presence of the drug causing platelet clearance. It has been previously proposed that the antibody binds the drug,
resulting in an immune complex that is then adsorbed onto platelets. However, it has been recently known that drug-dependent antibodies bind to one or more of the platelet
membrane glycoprotein Ib, lIb,IIIa, and IX.
We, hereby, report a case of rifampin-induced thrombocytopenia in which drug-dependent antibody specific for platelet glycoprotein Ib/IX and IIb/IIIa was
demonstrated by modified antigen capture ELISA method. The case was a 37 year-old female who had had pulmonary tuberculosis and taken antituberculous regimen including
rifampin. Intermittent epistaxis appeared 10 days after treatment with rifampin. She was admitted to hospital due to gingival bleeding for 3 days and menorrhagia for 2 days. On admission, her platelet count was dropped to 7,000/μL.
Keywords Rifampin; Thrombocytopenia; Drug-dependent antibody; Platelet glycoprotein Ib/IX and IIb/IIIa;
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Korean J Hematol 1998; 33(2): 284-288
Published online June 30, 1998
Copyright © The Korean Society of Hematology.
혈소판 Glycoprotein Ib/IX 및 Ⅱb/Ⅲa에 특이한 항체를 보인 Rifampin에 의한 혈소판 감소증 1례
강명서, 오도연, 김영철, 강신혜, 김현옥
포천중문의과대학 분당차병원 임상병리과,
포천중문의과대학 분당차병원 내과,
포천중문의과대학 분당차병원 소아과,
연세대학교 의과대학 임상병리과학교실
A Case of Rifampin-Induced Thrombocytopenia Associated with Specific Antibodies for Platelet Glycoprotein Ib/IX and llb/llla
Myung Seo Kang, Doyeun Oh, Young Cheol Kim, Shin Heh Kang, Hyun Ok Kim
Department of Clinical Pathology, Internal Medicine, Pediatrics, Pochun CHA University Medical College, Pundang CHA Hospital, Sungnam, Korea
Yonsei University College of Medicine, Seoul, Korea
Abstract
Rifampin is sometimes associated with hematologic complications such as hemolytic anemia or thrombocytopenia. Patients with drug-induced thrombocytopenia develop a
drug dependent antibody that binds to platelets in the presence of the drug causing platelet clearance. It has been previously proposed that the antibody binds the drug,
resulting in an immune complex that is then adsorbed onto platelets. However, it has been recently known that drug-dependent antibodies bind to one or more of the platelet
membrane glycoprotein Ib, lIb,IIIa, and IX.
We, hereby, report a case of rifampin-induced thrombocytopenia in which drug-dependent antibody specific for platelet glycoprotein Ib/IX and IIb/IIIa was
demonstrated by modified antigen capture ELISA method. The case was a 37 year-old female who had had pulmonary tuberculosis and taken antituberculous regimen including
rifampin. Intermittent epistaxis appeared 10 days after treatment with rifampin. She was admitted to hospital due to gingival bleeding for 3 days and menorrhagia for 2 days. On admission, her platelet count was dropped to 7,000/μL.
Keywords: Rifampin, Thrombocytopenia, Drug-dependent antibody, Platelet glycoprotein Ib/IX and IIb/IIIa,
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