Korean J Hematol 1997; 32(3):
Published online September 30, 1997
© The Korean Society of Hematology
급성 골수성 백혈병으로 이행된 본태성 혈소판증가증 1례
이지현, 김태익, 김근태, 이용환, 정선동, 장미화, 김호균, 김병창
메리놀병원 내과,
메리놀병원 임상병리과
A Case of Leukemic Transformation in Essential Thrombocythemia Treated with Hydroxyurea
Essential thrombocythemia is a myeloproliferative disorder, characterized by marked thrombocytosis and marrow megakaryocytic hyperplasia. Although the major causes of morbidity and mortality are bleeding and thromboembolic events, the long-term prognosis is favorable and leukemic transformation is rare.
We report a case of acute leukemia following treatment of Philadelphia chromosome-negative essential thrombocythemia with hydroxyurea for 4 years with a brief review of literature.
Keywords Leukemic transformation; Essential thrombocythemia; Hydroxyurea;
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Korean J Hematol 1997; 32(3): 433-439
Published online September 30, 1997
Copyright © The Korean Society of Hematology.
급성 골수성 백혈병으로 이행된 본태성 혈소판증가증 1례
이지현, 김태익, 김근태, 이용환, 정선동, 장미화, 김호균, 김병창
메리놀병원 내과,
메리놀병원 임상병리과
A Case of Leukemic Transformation in Essential Thrombocythemia Treated with Hydroxyurea
Ji Hyun Lee, Tae Ik Kim, Geun Tae Kim, Yong Hwan Lee, Sun Dong Jeong, Mi Hwa Jang, Ho Kyun Kim, Byung Chang Kim
Department of Internal Medicine, Clinical Pathology, Maryknoll Hospital, Pusan, Korea
Abstract
Essential thrombocythemia is a myeloproliferative disorder, characterized by marked thrombocytosis and marrow megakaryocytic hyperplasia. Although the major causes of morbidity and mortality are bleeding and thromboembolic events, the long-term prognosis is favorable and leukemic transformation is rare.
We report a case of acute leukemia following treatment of Philadelphia chromosome-negative essential thrombocythemia with hydroxyurea for 4 years with a brief review of literature.
Keywords: Leukemic transformation, Essential thrombocythemia, Hydroxyurea,
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