Korean J Hematol 2007; 42(1):
Published online March 30, 2007
https://doi.org/10.5045/kjh.2007.42.1.53
© The Korean Society of Hematology
이성규, 변성환, 최종운, 김현수
분당제생병원, 진단검사의학과, 소아과
Idiopathic CD4+ T-lymphocytopenia (ICL) is defined by the CDC as depressed numbers of circulating CD4+ T-lymphocytes (<300 cells/ՌL or <20% of the total T cells) on more than one determination, with the absence of HIV infection and other known causes of immunodeficiency. The clinical spectrum of ICL ranges from asymptomatic laboratory abnormalities to severe opportunistic infections that mimic the clinical course of human immunodeficiency virus (HIV) infected patients. There are a few reports of ICL associated with different diseases such as Sjogren's syndrome, pulmonary sarcoidosis, Down syndrome or non-Hodgkin's lymphoma. We describe here a 5-year-old male patient with a three-year history of recurrent otitis media and pulmonary infection, and he was without any risk factors for HIV infection; this patient presented with autoimmune hemolytic anemia and was ultimately found to have idiopathic CD4+ T-lymphocytopenia.
Keywords Idiopathic CD4+ T-lymphocytopenia, Otitis media, Pulmonary infection, Autoimmune hemolytic anemia
Korean J Hematol 2007; 42(1): 53-57
Published online March 30, 2007 https://doi.org/10.5045/kjh.2007.42.1.53
Copyright © The Korean Society of Hematology.
이성규, 변성환, 최종운, 김현수
분당제생병원, 진단검사의학과, 소아과
Seong Gyu Lee, Sung Hwan Byun, Jong Woon Choi, Hyun Soo Kim
Departments of, Laboratory Medicine and, Pediatrics, Bundang Jesaeng General Hospital, Seongnam, Korea
Idiopathic CD4+ T-lymphocytopenia (ICL) is defined by the CDC as depressed numbers of circulating CD4+ T-lymphocytes (<300 cells/ՌL or <20% of the total T cells) on more than one determination, with the absence of HIV infection and other known causes of immunodeficiency. The clinical spectrum of ICL ranges from asymptomatic laboratory abnormalities to severe opportunistic infections that mimic the clinical course of human immunodeficiency virus (HIV) infected patients. There are a few reports of ICL associated with different diseases such as Sjogren's syndrome, pulmonary sarcoidosis, Down syndrome or non-Hodgkin's lymphoma. We describe here a 5-year-old male patient with a three-year history of recurrent otitis media and pulmonary infection, and he was without any risk factors for HIV infection; this patient presented with autoimmune hemolytic anemia and was ultimately found to have idiopathic CD4+ T-lymphocytopenia.
Keywords: Idiopathic CD4+ T-lymphocytopenia, Otitis media, Pulmonary infection, Autoimmune hemolytic anemia
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