Blood Res 2019; 54(2):
Published online June 30, 2019
https://doi.org/10.5045/br.2019.54.2.120
© The Korean Society of Hematology
Correspondence to : Christianne Bourlon, M.D.
Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Belisario Domínguez Sección XVI, Tlalpan, C.P. 14080, Mexico City, Mexico
E-mail: chrisbourlon@hotmail.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
We conducted a retrospective case-control study from January 2010 to December 2015. Forty-two patients with hematologic malignancy and CDI, and 84 with hematologic disease and without history of CDI were included in the case and control groups, respectively.
Univariate analysis revealed that episodes of febrile eutropenia [odds ratio (OR), 5.5; 95% confidence interval (CI), 2.3–12.9;
The risk factors for developing CDI were exposure to therapeutic antibiotics and previous hospitalization. Hematological patients who developed CDI had higher early mortality rates, suggesting that new approaches for prevention and treatment are needed.
Keywords Clostridium difficile, Hematologic diseases, Risk factors, Tertiary care centers
Blood Res 2019; 54(2): 120-124
Published online June 30, 2019 https://doi.org/10.5045/br.2019.54.2.120
Copyright © The Korean Society of Hematology.
Yu Ling Lee-Tsai1, Rodrigo Luna-Santiago1, Roberta Demichelis-Gómez1, Alfredo Ponce-de-León2, Eric Ochoa-Hein3, Karla María Tamez-Torres2, María T Bourlon1, Christianne Bourlon1
1Department of Hematology and Oncology, 2Department of Infectology, 3Departament of Hospital Epidemiology and Quality Control of Medical Care, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Correspondence to:Christianne Bourlon, M.D.
Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Belisario Domínguez Sección XVI, Tlalpan, C.P. 14080, Mexico City, Mexico
E-mail: chrisbourlon@hotmail.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
We conducted a retrospective case-control study from January 2010 to December 2015. Forty-two patients with hematologic malignancy and CDI, and 84 with hematologic disease and without history of CDI were included in the case and control groups, respectively.
Univariate analysis revealed that episodes of febrile eutropenia [odds ratio (OR), 5.5; 95% confidence interval (CI), 2.3–12.9;
The risk factors for developing CDI were exposure to therapeutic antibiotics and previous hospitalization. Hematological patients who developed CDI had higher early mortality rates, suggesting that new approaches for prevention and treatment are needed.
Keywords: Clostridium difficile, Hematologic diseases, Risk factors, Tertiary care centers
Overall survival of cases and controls at 15 and 30 days.
Abbreviation: ICU, intensive care unit..
Abbreviations: GI, gastrointestinal; ICU, intensive care unit; PPI, proton pump inhibitors; Pr, prophylactic; Tx, therapeutic..
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Overall survival of cases and controls at 15 and 30 days.