Blood Res 2018; 53(4):
Published online December 31, 2018
https://doi.org/10.5045/br.2018.53.4.276
© The Korean Society of Hematology
Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan.
Correspondence to : Correspondence to Rafia Mahmood, MBBS, FCPS (Haem). Department of Haematology, Armed Forces Institute of Pathology, CMH Road, Rawalpindi, Punjab 46000, Pakistan. rafiamahmood@hotmail.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Chronic lymphocytic leukemia (CLL) exhibits profound heterogeneity in its clinical course. Its clinicohematological and cytogenetic features play a significant role in determining the clinical course and in predicting the treatment response and prognosis. In this context, 17p deletion is known to predict a poor prognosis, as these cases are refractory to conventional therapy. This study aimed to evaluate the clinicohematological characteristics, outcomes, and prognostic factors among CLL patients with and without del 17p in Pakistan.
This prospective observational study was conducted at the Department of Haematology, Armed Forces Institute of Pathology (Rawalpindi, Pakistan) between January 2013 and December 2017. Patients were diagnosed based on the International Workshop on Chronic Lymphocytic Leukaemia IWCLL criteria, their clinicohematological parameters were recorded, and cytogenetic analyses were performed. The time from diagnosis to treatment and the 2-year overall survival rate were also evaluated.
We evaluated 130 CLL cases, including 24 patients (18.5%) with del 17p, who included 18 men (75%) and 6 women (25%). The median age was 68 years. Binet stage C was detected at the presentation in 16 patients (67%). Treatment was administered to 14 patients (70%) at a median interval of 11 months (range, 0–28 mo) after diagnosis. The overall response rate was 64.3%, the median event-free survival was 9 months (range, 1–23 mo), and the 2-year overall survival rate was 65%.
Del 17p is relatively common in Pakistan, and patients harboring this deletion had poor treatment response and survival outcomes.
Keywords Chronic lymphocytic leukemia, Fluorescent in situ hybridization, Event-free survival, Overall survival
Blood Res 2018; 53(4): 276-280
Published online December 31, 2018 https://doi.org/10.5045/br.2018.53.4.276
Copyright © The Korean Society of Hematology.
Rafia Mahmood*, Saleem Ahmed Khan, Chaudhry Altaf, Hamid Saeed Malik, and Muhammad Tahir Khadim
Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan.
Correspondence to:Correspondence to Rafia Mahmood, MBBS, FCPS (Haem). Department of Haematology, Armed Forces Institute of Pathology, CMH Road, Rawalpindi, Punjab 46000, Pakistan. rafiamahmood@hotmail.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Chronic lymphocytic leukemia (CLL) exhibits profound heterogeneity in its clinical course. Its clinicohematological and cytogenetic features play a significant role in determining the clinical course and in predicting the treatment response and prognosis. In this context, 17p deletion is known to predict a poor prognosis, as these cases are refractory to conventional therapy. This study aimed to evaluate the clinicohematological characteristics, outcomes, and prognostic factors among CLL patients with and without del 17p in Pakistan.
This prospective observational study was conducted at the Department of Haematology, Armed Forces Institute of Pathology (Rawalpindi, Pakistan) between January 2013 and December 2017. Patients were diagnosed based on the International Workshop on Chronic Lymphocytic Leukaemia IWCLL criteria, their clinicohematological parameters were recorded, and cytogenetic analyses were performed. The time from diagnosis to treatment and the 2-year overall survival rate were also evaluated.
We evaluated 130 CLL cases, including 24 patients (18.5%) with del 17p, who included 18 men (75%) and 6 women (25%). The median age was 68 years. Binet stage C was detected at the presentation in 16 patients (67%). Treatment was administered to 14 patients (70%) at a median interval of 11 months (range, 0–28 mo) after diagnosis. The overall response rate was 64.3%, the median event-free survival was 9 months (range, 1–23 mo), and the 2-year overall survival rate was 65%.
Del 17p is relatively common in Pakistan, and patients harboring this deletion had poor treatment response and survival outcomes.
Keywords: Chronic lymphocytic leukemia, Fluorescent in situ hybridization, Event-free survival, Overall survival
Factors associated with prolonged event-free survival. Significantly prolonged event-free survival (EFS) was associated with the absence of B symptoms (
Data are shown as number (%) unless indicated otherwise..
Abbreviations: CLL, chronic lymphocytic leukemia; ECOG, Eastern Cooperative Oncology Group; LDH, lactate dehydrogenase..
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Factors associated with prolonged event-free survival. Significantly prolonged event-free survival (EFS) was associated with the absence of B symptoms (