Blood Res 2018; 53(3):
Published online September 28, 2018
https://doi.org/10.5045/br.2018.53.3.189
© The Korean Society of Hematology
Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Correspondence to : Correspondence to Cheolwon Suh, M.D., Ph.D. Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. csuh@amc.seoul.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The incidence of lymphoplasmacytic lymphoma (LPL) is lower in Asian than in Western populations. Few studies have described the clinical features and treatment outcomes of patients with LPL, including non-IgM LPL, in East Asia.
We retrospectively analyzed patients diagnosed with LPL at Asan Medical Center between January 2001 and March 2016. We evaluated the clinical features and survival outcomes of patients with LPL and non-IgM LPL and compared these data with those of patients with LPL/Waldenström's macroglobulinemia (WM).
The median age at diagnosis of patients with LPL was 61.5 years (range, 34–77 yr); most patients were male (91%). Approximately three-quarters of the 22 patients with LPL were in the low or intermediate risk groups according to the International Prognostic Scoring System for Waldenström's Macroglobulinemia classification. The median follow-up duration was 75 months [95% confidence interval (CI), 48–102 mo], and the median overall survival (OS) was 81 months (95% CI, 0–167 mo). The number of patients in the non-IgM LPL group who exhibited extramedullary involvement was higher than in the LPL/WM group. OS of the LPL/WM group was improved compared with that of the non-IgM LPL group [median not reached vs. 10.0 mo (95% CI, 0–36.7);
We present a single-center experience of 22 patients with LPL, including a non-IgM cohort, in Korea. The treatment of non-IgM LPL was heterogeneous, and patients with non-IgM LPL showed a higher 5-year mortality rate and more adverse prognostic factors than those with LPL/WM.
Keywords Lymphoplasmacytic lymphoma, Non-IgM, Waldenström's macroglobulinemia
Blood Res 2018; 53(3): 189-197
Published online September 28, 2018 https://doi.org/10.5045/br.2018.53.3.189
Copyright © The Korean Society of Hematology.
Jihoon Kang, Jung Yong Hong, and Cheolwon Suh*
Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Correspondence to:Correspondence to Cheolwon Suh, M.D., Ph.D. Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. csuh@amc.seoul.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The incidence of lymphoplasmacytic lymphoma (LPL) is lower in Asian than in Western populations. Few studies have described the clinical features and treatment outcomes of patients with LPL, including non-IgM LPL, in East Asia.
We retrospectively analyzed patients diagnosed with LPL at Asan Medical Center between January 2001 and March 2016. We evaluated the clinical features and survival outcomes of patients with LPL and non-IgM LPL and compared these data with those of patients with LPL/Waldenström's macroglobulinemia (WM).
The median age at diagnosis of patients with LPL was 61.5 years (range, 34–77 yr); most patients were male (91%). Approximately three-quarters of the 22 patients with LPL were in the low or intermediate risk groups according to the International Prognostic Scoring System for Waldenström's Macroglobulinemia classification. The median follow-up duration was 75 months [95% confidence interval (CI), 48–102 mo], and the median overall survival (OS) was 81 months (95% CI, 0–167 mo). The number of patients in the non-IgM LPL group who exhibited extramedullary involvement was higher than in the LPL/WM group. OS of the LPL/WM group was improved compared with that of the non-IgM LPL group [median not reached vs. 10.0 mo (95% CI, 0–36.7);
We present a single-center experience of 22 patients with LPL, including a non-IgM cohort, in Korea. The treatment of non-IgM LPL was heterogeneous, and patients with non-IgM LPL showed a higher 5-year mortality rate and more adverse prognostic factors than those with LPL/WM.
Keywords: Lymphoplasmacytic lymphoma, Non-IgM, Waldenström's macroglobulinemia
Overall survival
Overall survival
a)One patient with LPL/WM was excluded because of missing data for β2-MG. b)Two patients with LPL/WM were excluded because of missing data for cytogenetics..
Abbreviations: β2-MG, beta2-microglobulin; BM, bone marrow; ECOG PS, Eastern Cooperative Oncology Group Performance Status; ISSWM, International Prognostic Scoring System for Waldenström's Macroglobulinemia; LDH, lactate dehydrogenase; LPL, lymphoplasmacytic lymphoma; WM, Waldenström's macroglobulinemia..
Abbreviations: BM, bone marrow; GIT, gastrointestinal tract; LN, lymph node; LPL, lymphoplasmacytic lymphoma; OS, overall survival; BR, bendamustine+rituximab; R, rituximab; CHOP, cyclophosphamide+doxorubicin+vincristine+prednisolone; C(V)P, cyclophosphamide+(vincristine)+prednisolone; FDR, fludarabine; HD-dex, high-dose dexamethasone; HD-MA, high-dose methotrexate+ara-C; ICE-dex, ifosfamide+carboplatin+etoposide+dexamethasone; MP, melphalan+prednisolone; VAD, vincristine+doxorubicin+dexamethasone; VMP, bortezomib+melphalan+prednisolone; ISSWM, International Prognostic Scoring System for Waldenstrom Macroglobulinemia; Int, Intermediate; CR, complete response; PR, partial response; MR, minimal response; SD, stable disease; PD, progressive disease..
Abbreviations: CI, confidence interval; LPL, lymphoplasmacytic lymphoma; OS, overall survival; PFS, progression-free survival; WM, Waldenström's macroglobulinemia..
Sang-Yong Shin, Seung-Tae Lee, Hyun-Young Kim, Chang-Hun Park, Hee-Jin Kim, Jong-Won Kim, Seok Jin Kim, Won Seog Kim, and Sun-Hee Kim
Blood Res 2016; 51(3): 181-186
Overall survival
Overall survival