Blood Res 2016; 51(2):
Published online June 23, 2016
https://doi.org/10.5045/br.2016.51.2.102
© The Korean Society of Hematology
1Department of Infectious Diseases, Belarusian State Medical University, Minsk, Belarus.
2Department of Infectious Diseases, City Clinical Hospital №9, Minsk, Belarus.
Correspondence to : Correspondence to Igor Stoma, M.D. Department of Infectious Diseases, Belarusian State Medical University, Prititskogo str., 2-2-105, 220073, Minsk, Belarus. igor.stoma@gmail.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Bloodstream infections (BSI) remain a frequent complication during the pre-engraftment period after hematopoietic stem cell transplantation (HSCT), resulting in high mortality rates. This study evaluated risk factors for mortality in hematopoietic stem cell transplant recipients with BSI in the pre-engraftment period.
This prospective case control study was performed at the Center of Hematology and Bone Marrow Transplantation in Minsk, Republic of Belarus. Data relating to patient age and gender, date and type of transplantation, conditioning chemotherapy regimen, microorganisms isolated from blood, and antibacterial therapy were prospectively collected from all hematopoietic stem cell recipients with microbiologically proven cases of BSI in the pre-engraftment period. The primary outcome was all-cause 30-day mortality after onset of febrile neutropenia.
A total of 135 adult patients with microbiologically proven BSI after HSCT were studied, with 65.2% of cases caused by gram-negative microorganisms and 21.5% by non-fermenting bacteria. Inadequate empiric antibacterial therapy and isolation of carbapenem-resistant non-fermenting gram-negative bacteria (
The risk factors for mortality in adult patients with BSI in the pre-engraftment period after HSCT were inadequacy of empirical antibacterial therapy and isolation of carbapenem-resistant
Keywords Hematopoietic stem cell transplantation, Bloodstream infection, Risk factors, Antibacterial therapy
Blood Res 2016; 51(2): 102-106
Published online June 23, 2016 https://doi.org/10.5045/br.2016.51.2.102
Copyright © The Korean Society of Hematology.
Igor Stoma1*, Igor Karpov1, Natalia Milanovich2, Anatoly Uss2, and Igor Iskrov2
1Department of Infectious Diseases, Belarusian State Medical University, Minsk, Belarus.
2Department of Infectious Diseases, City Clinical Hospital №9, Minsk, Belarus.
Correspondence to: Correspondence to Igor Stoma, M.D. Department of Infectious Diseases, Belarusian State Medical University, Prititskogo str., 2-2-105, 220073, Minsk, Belarus. igor.stoma@gmail.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Bloodstream infections (BSI) remain a frequent complication during the pre-engraftment period after hematopoietic stem cell transplantation (HSCT), resulting in high mortality rates. This study evaluated risk factors for mortality in hematopoietic stem cell transplant recipients with BSI in the pre-engraftment period.
This prospective case control study was performed at the Center of Hematology and Bone Marrow Transplantation in Minsk, Republic of Belarus. Data relating to patient age and gender, date and type of transplantation, conditioning chemotherapy regimen, microorganisms isolated from blood, and antibacterial therapy were prospectively collected from all hematopoietic stem cell recipients with microbiologically proven cases of BSI in the pre-engraftment period. The primary outcome was all-cause 30-day mortality after onset of febrile neutropenia.
A total of 135 adult patients with microbiologically proven BSI after HSCT were studied, with 65.2% of cases caused by gram-negative microorganisms and 21.5% by non-fermenting bacteria. Inadequate empiric antibacterial therapy and isolation of carbapenem-resistant non-fermenting gram-negative bacteria (
The risk factors for mortality in adult patients with BSI in the pre-engraftment period after HSCT were inadequacy of empirical antibacterial therapy and isolation of carbapenem-resistant
Keywords: Hematopoietic stem cell transplantation, Bloodstream infection, Risk factors, Antibacterial therapy
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