Blood Res 2013; 48(1):
Published online March 31, 2013
https://doi.org/10.5045/br.2013.48.1.51
© The Korean Society of Hematology
Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, India.
Correspondence to : Correspondence to Nitin Agarwal, M.D. Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi 110029, India. Tel: +91-9335620018, Fax: +91-11-26588641, nuts_medico@rediffmail.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Knowledge about the frequency of red blood cell-antigen phenotypes in a population can be helpful in the creation of a donor data bank for the preparation of indigenous cell panels and for providing antigen-negative compatible blood to patients with multiple alloantibodies.
ABO and RhD blood grouping was performed on 9,280 continuous voluntary and replacement donors. For other rare blood groups, 508 ACD blood samples were obtained from the donors at the Blood Bank of the Department of Transfusion Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. Blood group antigens were determined by tube method using anti-sera (Bio-Rad, USA), and the phenotype frequencies were expressed as percentages.
Group B (37.39%) was the most common, followed by group O (31.85%). R1R1 and rr were the most common phenotypes amongst Rh positive and Rh negative groups, respectively. A rare phenotype R2Rz was found in one donor. For Kidd and Duffy blood group systems, Jk (a+b+) and Fy (a+b+) were the most common phenotypes (46.06% and 48.03%, respectively). The most common phenotypes for MNSs, Lu, and Kell blood groups were M+N+, S-s+, Lu (a-b+), and K-k+, respectively. A very rare case of Fy (a-b-) and Jk (a-b-) was found in a single donor.
This study is the first small step to create a rare donor data bank and to prepare indigenous cell panels to provide compatible blood to all multi-transfused alloimmunized patients.
Keywords Blood group, MNS, ABO, Rh, Kell, Kidd, Duffy
Blood Res 2013; 48(1): 51-54
Published online March 31, 2013 https://doi.org/10.5045/br.2013.48.1.51
Copyright © The Korean Society of Hematology.
Nitin Agarwal, Rakesh Mohan Thapliyal, and Kabita Chatterjee*
Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, India.
Correspondence to:Correspondence to Nitin Agarwal, M.D. Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi 110029, India. Tel: +91-9335620018, Fax: +91-11-26588641, nuts_medico@rediffmail.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Knowledge about the frequency of red blood cell-antigen phenotypes in a population can be helpful in the creation of a donor data bank for the preparation of indigenous cell panels and for providing antigen-negative compatible blood to patients with multiple alloantibodies.
ABO and RhD blood grouping was performed on 9,280 continuous voluntary and replacement donors. For other rare blood groups, 508 ACD blood samples were obtained from the donors at the Blood Bank of the Department of Transfusion Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. Blood group antigens were determined by tube method using anti-sera (Bio-Rad, USA), and the phenotype frequencies were expressed as percentages.
Group B (37.39%) was the most common, followed by group O (31.85%). R1R1 and rr were the most common phenotypes amongst Rh positive and Rh negative groups, respectively. A rare phenotype R2Rz was found in one donor. For Kidd and Duffy blood group systems, Jk (a+b+) and Fy (a+b+) were the most common phenotypes (46.06% and 48.03%, respectively). The most common phenotypes for MNSs, Lu, and Kell blood groups were M+N+, S-s+, Lu (a-b+), and K-k+, respectively. A very rare case of Fy (a-b-) and Jk (a-b-) was found in a single donor.
This study is the first small step to create a rare donor data bank and to prepare indigenous cell panels to provide compatible blood to all multi-transfused alloimmunized patients.
Keywords: Blood group, MNS, ABO, Rh, Kell, Kidd, Duffy
Table 1 . ABO and D blood group distribution (N=9,280)..
Table 2 . Rh phenotypes frequency in north Indian donors..
Table 3 . Phenotype frequencies of Lewis, Kell, Kidd, Duffy, and Lutheran blood group systems (compared to other published data)..
Abbreviations: K, Kell; Fy, Duffy; Le, Lewis; Jk, Kidd; Lu, Lutheran; ND, not done..
Table 4 . Phenotype frequencies of MNSs blood group system (Compared to other published data)..
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