Korean J Hematol 2010; 45(4):
Published online December 31, 2010
https://doi.org/10.5045/kjh.2010.45.4.282
© The Korean Society of Hematology
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Correspondence to : Correspondence to Dong-Wan Kim, M.D., Ph.D. Department of Internal Medicine, Seoul National University Hospital, 101, Daehagro, Chongno-gu, Seoul 110-744, Korea. Tel: +82-2-2072-2995, Fax: +82-2-762-9662, kimdw@snu.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Primary cardiac lymphoma (PCL) is a rare disease entity with only a few reported cases in Korea. In this paper, we report a case of PCL in a 59-year-old man presenting with chest pain. Diffuse large B-cell lymphoma was diagnosed through a cardiac catheterization-assisted percutaneous endomyocardial biopsy, and there was no evidence of extracardiac involvement of the lymphoma.The patient had a complete clinical response after systemic chemotherapy with a rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) regimen and additional post-chemotherapeutic radiation therapy. The patient experienced a long-term disease-free survival of over 4 years. However, he received coronary artery bypass graft surgery due to an acute myocardial infarction that occurred 3 years after the completion of the radiation therapy. Although the addition of radiation therapy to the treatment is thought to decrease the risk of relapse in patients with PCL, a careful and thorough consideration of the potential complications of radiation therapy, particularly with respect to cardiac complications, should be considered.
Keywords Lymphoma, Myocardial infarction, Drug therapy, Radiotherapy
Korean J Hematol 2010; 45(4): 282-285
Published online December 31, 2010 https://doi.org/10.5045/kjh.2010.45.4.282
Copyright © The Korean Society of Hematology.
Dong-Yeop Shin, Yun-Gyoo Lee, Hyun-Jung Lee, Seyoun Choi, Jin Joo Park, and Dong-Wan Kim*
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Correspondence to: Correspondence to Dong-Wan Kim, M.D., Ph.D. Department of Internal Medicine, Seoul National University Hospital, 101, Daehagro, Chongno-gu, Seoul 110-744, Korea. Tel: +82-2-2072-2995, Fax: +82-2-762-9662, kimdw@snu.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Primary cardiac lymphoma (PCL) is a rare disease entity with only a few reported cases in Korea. In this paper, we report a case of PCL in a 59-year-old man presenting with chest pain. Diffuse large B-cell lymphoma was diagnosed through a cardiac catheterization-assisted percutaneous endomyocardial biopsy, and there was no evidence of extracardiac involvement of the lymphoma.The patient had a complete clinical response after systemic chemotherapy with a rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) regimen and additional post-chemotherapeutic radiation therapy. The patient experienced a long-term disease-free survival of over 4 years. However, he received coronary artery bypass graft surgery due to an acute myocardial infarction that occurred 3 years after the completion of the radiation therapy. Although the addition of radiation therapy to the treatment is thought to decrease the risk of relapse in patients with PCL, a careful and thorough consideration of the potential complications of radiation therapy, particularly with respect to cardiac complications, should be considered.
Keywords: Lymphoma, Myocardial infarction, Drug therapy, Radiotherapy
Table 1 . Baseline characteristics of the long-term follow-up cases (≥1 year) with primary cardiac lymphoma treated with systemic chemotherapy (Data are from 13 cases, including the present case)..
Abbreviations: DLBL, diffuse large B-cell lymphoma; RA, right atrium; RV, right ventricle..
Table 2 . Long-term outcomes of cases of primary cardiac lymphoma treated with systemic chemotherapy (Data are from 13 cases, including the one detailed in the current case report)..
a)All patients received anthracycline-containing combination chemotherapy..
Abbreviations: PFS, progression free survival; RTx, radiation therapy..
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