Korean J Hematol 2006; 41(3):
Published online September 30, 2006
https://doi.org/10.5045/kjh.2006.41.3.220
© The Korean Society of Hematology
김용범, 이지정, 김선영, 김미진, 설지영, 길홍량
충남대학교 의과대학, 소아과학교실, 외과학교실
Although indwelling central venous catheters guarantee a reliable vascular access, and are essential for the management of children undergoing anticancer chemotherapy or stem cell transplantation, these catheters may cause serious mechanical, infectious and thrombotic complications. Central venous catheter-related thrombosis is one of the most important complications that may interfere with the course of treatment. A number of regimens utilizing urokinase have been used but the optimum management of this common problem remains undetermined. We report an 8 year-old boy, who had catheter-related atrial thrombus treated successfully with urokinase. A short course treatment with the use of low-dose urokinase was feasible for the thrombolysis of catheter-related right atrial thrombus in this boy diagnosed with neuroblastoma and undergoing high-dose chemotherapy with autologous peripheral blood stem cell rescue. This treatment was not associated with bleeding.
Keywords Catheter-related thrombosis, Urokinase
Korean J Hematol 2006; 41(3): 220-223
Published online September 30, 2006 https://doi.org/10.5045/kjh.2006.41.3.220
Copyright © The Korean Society of Hematology.
김용범, 이지정, 김선영, 김미진, 설지영, 길홍량
충남대학교 의과대학, 소아과학교실, 외과학교실
Yong Beom Kim, Ji Joung Lee, Sun Young Kim, Mi Jin Kim, Ji Young Sul, Hong Ryang Kil
Departments of, Pediatrics and, Surgery, Chungnam National University College of Medicine, Daejeon, Korea
Although indwelling central venous catheters guarantee a reliable vascular access, and are essential for the management of children undergoing anticancer chemotherapy or stem cell transplantation, these catheters may cause serious mechanical, infectious and thrombotic complications. Central venous catheter-related thrombosis is one of the most important complications that may interfere with the course of treatment. A number of regimens utilizing urokinase have been used but the optimum management of this common problem remains undetermined. We report an 8 year-old boy, who had catheter-related atrial thrombus treated successfully with urokinase. A short course treatment with the use of low-dose urokinase was feasible for the thrombolysis of catheter-related right atrial thrombus in this boy diagnosed with neuroblastoma and undergoing high-dose chemotherapy with autologous peripheral blood stem cell rescue. This treatment was not associated with bleeding.
Keywords: Catheter-related thrombosis, Urokinase