Image of Hematology
Split Viewer
Blood Res 2022; 57(3):
Published online September 30, 2022
https://doi.org/10.5045/br.2022.2022135
© The Korean Society of Hematology
Cabot ring-like faggot cells in acute promyelocytic leukemia
Correspondence to : Atakan Turgutkaya, M.D., Division of Hematology, Aydin Adnan Menderes University Medical Faculty, 09100 Aydin, Turkey, E-mail: atakanturgutkaya@yahoo.com.tr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
A 27-year-old man presented with a 2-month history of fatigue and ecchymotic patches covering his body. On systemic examination, there was no organomegaly or lymphadenopathy. His hemoglobin was 8.6 g/dL, total leucocyte count was 2.1×109/L, and platelet count was 32×109/L. The patient was determined to be t (15;17) positive by PCR and FISH analysis, and was diagnosed with acute promyelocytic leukemia (APL) with Auer body formation surrounding the nucleus (A, B) based on a bone marrow aspirated smear image.
Auer rods are elongated, azurophilic cytoplasmic inclusions in myeloid leukemic blasts. Their presence confirms a diagnosis of acute myeloid leukemia. In APL, multiple such inclusion bodies may be observed, and may occur in clusters (faggots). Faggot cells are bundles of stick-like Auer rods formed by coalescence of primary granules. Their presence, although reported in other types of leukemia, is a morphological clue suggesting APL. They usually form random clusters in the cytoplasm of promyelocytes or blasts. To our knowledge, ring-shaped Auer body formation in a promyelocyte or blast resembling a Cabot ring in the erythrocyte has not been previously reported.
PDF
Standard view
Export citation
Share Article
Image of Hematology
Blood Res 2022; 57(3): 174-174
Published online September 30, 2022 https://doi.org/10.5045/br.2022.2022135
Copyright © The Korean Society of Hematology.
Cabot ring-like faggot cells in acute promyelocytic leukemia
Irfan Yavasoglu, Atakan Turgutkaya, Ali Zahit Bolaman
Division of Hematology, Aydin Adnan Menderes University Medical Faculty, Aydin, Turkey
Correspondence to:Atakan Turgutkaya, M.D., Division of Hematology, Aydin Adnan Menderes University Medical Faculty, 09100 Aydin, Turkey, E-mail: atakanturgutkaya@yahoo.com.tr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Body
A 27-year-old man presented with a 2-month history of fatigue and ecchymotic patches covering his body. On systemic examination, there was no organomegaly or lymphadenopathy. His hemoglobin was 8.6 g/dL, total leucocyte count was 2.1×109/L, and platelet count was 32×109/L. The patient was determined to be t (15;17) positive by PCR and FISH analysis, and was diagnosed with acute promyelocytic leukemia (APL) with Auer body formation surrounding the nucleus (A, B) based on a bone marrow aspirated smear image.
Auer rods are elongated, azurophilic cytoplasmic inclusions in myeloid leukemic blasts. Their presence confirms a diagnosis of acute myeloid leukemia. In APL, multiple such inclusion bodies may be observed, and may occur in clusters (faggots). Faggot cells are bundles of stick-like Auer rods formed by coalescence of primary granules. Their presence, although reported in other types of leukemia, is a morphological clue suggesting APL. They usually form random clusters in the cytoplasm of promyelocytes or blasts. To our knowledge, ring-shaped Auer body formation in a promyelocyte or blast resembling a Cabot ring in the erythrocyte has not been previously reported.
Previous Article
