Blood Res 2019; 54(4):
Published online December 31, 2019
https://doi.org/10.5045/br.2019.54.4.243
© The Korean Society of Hematology
Correspondence to : Fran?ois Vergez, Ph.D., Laboratory of Haematology, Institut Universitaire du Cancer de Toulouse (IUCT) - Oncopole, 1 avenue Ir?ne Joliot-Curie, Toulouse 31100, France, E-mail: vergez.francois@iuct-oncopole.fr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
A 48-year-old woman with rheumatoid arthritis followed for five years was referred to our facility due to unexplained neutropenia. Except for inflammatory syndrome, blood biochemistry results were normal. Complete blood count revealed slight thrombocytopenia (146×109/L) and moderate neutropenia (0.57×109/L). Clinical examination was otherwise normal. Blood smear revealed increased large granular lymphocytes (3.5×109/L) representing 60% of leukocytes (
T-LGL leukemias are rare lymphoproliferative diseases defined by CD3+ cytotoxic clonal expansion. γδ T-LGL leukemias are commonly associated with rheumatoid arthritis, neutropenia, and thrombocytopenia. They share similar indolent course with classical alpha beta T-LGL leukemias. Thus, γδ T-LGL leukemias need to be distinguished from aggressive γδ T-cell lymphomas (such as hepatosplenic and cutaneous γδ T-cell lymphomas).
Blood Res 2019; 54(4): 243-243
Published online December 31, 2019 https://doi.org/10.5045/br.2019.54.4.243
Copyright © The Korean Society of Hematology.
François Vergez1, Laetitia Largeaud1, Lucie Oberic2, Jean-Baptiste Rieu1
1Laboratory of Haematology, 2Department of Haematology, University Cancer Institute of Toulouse, Toulouse, France
Correspondence to:Fran?ois Vergez, Ph.D., Laboratory of Haematology, Institut Universitaire du Cancer de Toulouse (IUCT) - Oncopole, 1 avenue Ir?ne Joliot-Curie, Toulouse 31100, France, E-mail: vergez.francois@iuct-oncopole.fr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
A 48-year-old woman with rheumatoid arthritis followed for five years was referred to our facility due to unexplained neutropenia. Except for inflammatory syndrome, blood biochemistry results were normal. Complete blood count revealed slight thrombocytopenia (146×109/L) and moderate neutropenia (0.57×109/L). Clinical examination was otherwise normal. Blood smear revealed increased large granular lymphocytes (3.5×109/L) representing 60% of leukocytes (
T-LGL leukemias are rare lymphoproliferative diseases defined by CD3+ cytotoxic clonal expansion. γδ T-LGL leukemias are commonly associated with rheumatoid arthritis, neutropenia, and thrombocytopenia. They share similar indolent course with classical alpha beta T-LGL leukemias. Thus, γδ T-LGL leukemias need to be distinguished from aggressive γδ T-cell lymphomas (such as hepatosplenic and cutaneous γδ T-cell lymphomas).