Korean J Hematol 2009; 44(4):
Published online December 30, 2009
https://doi.org/10.5045/kjh.2009.44.4.249
© The Korean Society of Hematology
김정은 서일혜 박필환 김경희 송영희 박순호 서을주 안정열
가천의대 길병원 진단검사의학과,
울산대학교 의과대학 서울아산병원 진단검사의학과
Biphenotypic acute leukemia (BAL) is a rare type of leukemia, comprises 4% of all acute leukemias. It is more common in adults and the clinical features, as related to marrow dysfunction, are similar to those found in other patients with acute leukemia. BAL commonly shows a dimorphic blast population with, one resembling lymphoblasts and the other resembling myeloblasts. The majority of BAL patients express B-lymphoid and myeloid markers. BAL can be diagnosed by morphologic studies and by a comprehensive panel of immunological markers, as well as cytogenetic/molecular studies, such as fluorescence in situ hybridization (FISH) and reverse transcriptase-polymerase chain reaction (RT-PCR). In addition, its prognosis is relatively poor. We present here a 27 year-old female patient who showed lymphoblasts and myeloblasts on her marrow studies and these cells were positive for myeloid and B-lymphoid markers on the immunophenotypic studies. Chromosome analysis revealed 46,XX,t(6;19)(p23;p13.1),t(9;22)(q34;q11.2). A major (b3a2) type of BCR-ABL1 mRNA transcript was detected by RT-PCR, and a 5'ABL1 deletion was identified by FISH. (Korean J Hematol 2009;44:249-254.)
Keywords Biphenotypic acute leukemia (BAL), t(9;22)(q34;q11.2), BCR-ABL1 mRNA transcript, 5'ABL1 deletion
Korean J Hematol 2009; 44(4): 249-254
Published online December 30, 2009 https://doi.org/10.5045/kjh.2009.44.4.249
Copyright © The Korean Society of Hematology.
김정은 서일혜 박필환 김경희 송영희 박순호 서을주 안정열
가천의대 길병원 진단검사의학과,
울산대학교 의과대학 서울아산병원 진단검사의학과
Jung Eun Kim, Yiel Hea Seo, Pil Hwan Park, Kyung Hee Kim, Young Hee Song, Soon Ho Park, Eul Ju Seo, Jeong Yeal Ahn
Department of Laboratory Medicine, Gachon University Gil Hospital, Incheon
University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
Biphenotypic acute leukemia (BAL) is a rare type of leukemia, comprises 4% of all acute leukemias. It is more common in adults and the clinical features, as related to marrow dysfunction, are similar to those found in other patients with acute leukemia. BAL commonly shows a dimorphic blast population with, one resembling lymphoblasts and the other resembling myeloblasts. The majority of BAL patients express B-lymphoid and myeloid markers. BAL can be diagnosed by morphologic studies and by a comprehensive panel of immunological markers, as well as cytogenetic/molecular studies, such as fluorescence in situ hybridization (FISH) and reverse transcriptase-polymerase chain reaction (RT-PCR). In addition, its prognosis is relatively poor. We present here a 27 year-old female patient who showed lymphoblasts and myeloblasts on her marrow studies and these cells were positive for myeloid and B-lymphoid markers on the immunophenotypic studies. Chromosome analysis revealed 46,XX,t(6;19)(p23;p13.1),t(9;22)(q34;q11.2). A major (b3a2) type of BCR-ABL1 mRNA transcript was detected by RT-PCR, and a 5'ABL1 deletion was identified by FISH. (Korean J Hematol 2009;44:249-254.)
Keywords: Biphenotypic acute leukemia (BAL), t(9,22)(q34,q11.2), BCR-ABL1 mRNA transcript, 5'ABL1 deletion