Korean J Hematol 2008; 43(1):
Published online March 30, 2008
https://doi.org/10.5045/kjh.2008.43.1.28
© The Korean Society of Hematology
박은실, 김인숙, 전진수, 서지현, 임재영, 박찬후, 우향옥, 윤희상
경상대학교 의과대학 소아청소년학교실, 진단검사의학교실
Background:
The incidence of iron deficiency anaemia in infants, which is caused by the increased iron demand for rapid growth during this period, is reported to range from 10 to 40%. This age group also suffers from a number of acute illnesses (urinary tract infection, pneumonia and other viral illness). The aim of this study was to evaluate the usefulness of soluble transferrin receptor (sTfR) values and the different methods of calculating the sTfR and serum ferritin (SF) ratio for differentiating anemia of inflammation (AI) from iron deficiency anemia (IDA) or a mixture of these two types of anemia.
Methods:
173 infants among all the infants who visited Gyeongsang National University Hospital from 2000 to 2006 were enrolled in this study. The hemoglobin (Hb), SF and sTfR values were checked and the infants were divided into the Al subgroup (Hb <11g/dL and SF >50Ռg/L), the IDA subgroup (Hb <11g/dL and SF <12Ռg/L), the normal group (Hb ≥11g/dL and SF ≥12Ռg/L), and the unclassified anemia (UCA) group (Hb <11g/dL and SF 12∼50Ռg/L).
Results:
The mean sTfR and sTfR/Log SF values in the AI group were 3.89 and 10.6Ռg/mL, respectively (P<0.01). These values in the IDA group were 1.9 and 36.11, respectively (P<0.01). The mean Log (sTfR/SF) was statistically significant between all the subgroups (1.35 in AI, 3.29 in IDA, 1.76 in Nor and 2.35 in UCA). All the infants in the IDA group had a Log (sTfR/SF) value >2.55 whereas all the infants classified in AI group had a Log (sTfR/SF) value <2.55.
Conclusion:
The Log (sTfR/SF) value is a useful criterion for discriminating between AI and IDA.
Keywords Anemia, Iron deficiency, Inflammation, Receptors transferrin, Ferritins, Infants
Korean J Hematol 2008; 43(1): 28-33
Published online March 30, 2008 https://doi.org/10.5045/kjh.2008.43.1.28
Copyright © The Korean Society of Hematology.
박은실, 김인숙, 전진수, 서지현, 임재영, 박찬후, 우향옥, 윤희상
경상대학교 의과대학 소아청소년학교실, 진단검사의학교실
Eun Sil Park, In Suk Kim, Jin Su Jun, Ji Hyun Seo, Jae Young Lim, Chan Hoo Park, Hyang Ok Woo, Hee Shang Youn
Departments of Pediatrics and Diagnostic Laboratory, Gyeongsang National University College of Medicine, Jinju, Korea
Background:
The incidence of iron deficiency anaemia in infants, which is caused by the increased iron demand for rapid growth during this period, is reported to range from 10 to 40%. This age group also suffers from a number of acute illnesses (urinary tract infection, pneumonia and other viral illness). The aim of this study was to evaluate the usefulness of soluble transferrin receptor (sTfR) values and the different methods of calculating the sTfR and serum ferritin (SF) ratio for differentiating anemia of inflammation (AI) from iron deficiency anemia (IDA) or a mixture of these two types of anemia.
Methods:
173 infants among all the infants who visited Gyeongsang National University Hospital from 2000 to 2006 were enrolled in this study. The hemoglobin (Hb), SF and sTfR values were checked and the infants were divided into the Al subgroup (Hb <11g/dL and SF >50Ռg/L), the IDA subgroup (Hb <11g/dL and SF <12Ռg/L), the normal group (Hb ≥11g/dL and SF ≥12Ռg/L), and the unclassified anemia (UCA) group (Hb <11g/dL and SF 12∼50Ռg/L).
Results:
The mean sTfR and sTfR/Log SF values in the AI group were 3.89 and 10.6Ռg/mL, respectively (P<0.01). These values in the IDA group were 1.9 and 36.11, respectively (P<0.01). The mean Log (sTfR/SF) was statistically significant between all the subgroups (1.35 in AI, 3.29 in IDA, 1.76 in Nor and 2.35 in UCA). All the infants in the IDA group had a Log (sTfR/SF) value >2.55 whereas all the infants classified in AI group had a Log (sTfR/SF) value <2.55.
Conclusion:
The Log (sTfR/SF) value is a useful criterion for discriminating between AI and IDA.
Keywords: Anemia, Iron deficiency, Inflammation, Receptors transferrin, Ferritins, Infants
Dong Hyun Kim, Sung Jin Kim, Soon Ki Kim, Byong Kwan Son, Han Ik Cho
Korean J Hematol 2007; 42(4): 367-374Soon Ki Kim, Chul Soo Kim, Jong Weon Choi,
Mi Hye Cho, Kwang Hoi Kim, Kyung Ja Chang
Woo Sik Cheong, Seung Baik Han, Jong Woon Choi, Soon Ki Kim, Byong Kwan Son
Korean J Hematol 1995; 30(1): 59-67