Korean J Hematol 2004; 39(2):
Published online June 30, 2004
© The Korean Society of Hematology
이영호, 이승원, 노규태, 이영석, 이영아
동아대학교 의과대학 소아과학교실
PURPOSE :
We experienced the early toxicities in preengraftment period following cord blood stem cell transplantation (CBSCT), mimicking engraftment syndrome, characterized by fever, skin rash and fluid retention. We report these toxicities here, first in Korea, as an early inflammatory syndrome (EIS).
METHODS :
We retrospectively reviewed the clinical data of 13 patients who received CBSCT with conventional conditioning chemotherapy for hematologic malignancies and immunodeficiency at Dong-A University Medical Center from 1998 to 2003. We defined the criteria for EIS as follows:noninfectious fever, skin rashes mimicking acute graft versus host disease and the evidence of fluid retention. These clinical signs should be appeared before neutrophil engraftment.
RESULTS :
We experienced 3 cases of EIS in patients received the conventional dosage of conditioning chemotherapy for CBSCT, which developed on post-transplant day 7~10 and persisted for 2~7 days. Two out of 3 patients were recovered from EIS spontaneously or by supportive treatment, except 1 patient who expired due to complicated pulmonary hemorrhage.
CONCLUSION :
The definition of EIS is yet obscure, thus more close observations for clinical course of CBSCT and pathophysiological research would be required.
Keywords Early inflammatory syndrome, Engraftment syndrome, Cord blood stem cell transpantation
Korean J Hematol 2004; 39(2): 66-70
Published online June 30, 2004
Copyright © The Korean Society of Hematology.
이영호, 이승원, 노규태, 이영석, 이영아
동아대학교 의과대학 소아과학교실
Young Ho Lee, Seung Won Lee, Kyu Tae Noh, Young Seok Lee, Young Ah Lee
Department of Pediatrics, Dong, A University, College of Medicine, Busan, Korea
PURPOSE :
We experienced the early toxicities in preengraftment period following cord blood stem cell transplantation (CBSCT), mimicking engraftment syndrome, characterized by fever, skin rash and fluid retention. We report these toxicities here, first in Korea, as an early inflammatory syndrome (EIS).
METHODS :
We retrospectively reviewed the clinical data of 13 patients who received CBSCT with conventional conditioning chemotherapy for hematologic malignancies and immunodeficiency at Dong-A University Medical Center from 1998 to 2003. We defined the criteria for EIS as follows:noninfectious fever, skin rashes mimicking acute graft versus host disease and the evidence of fluid retention. These clinical signs should be appeared before neutrophil engraftment.
RESULTS :
We experienced 3 cases of EIS in patients received the conventional dosage of conditioning chemotherapy for CBSCT, which developed on post-transplant day 7~10 and persisted for 2~7 days. Two out of 3 patients were recovered from EIS spontaneously or by supportive treatment, except 1 patient who expired due to complicated pulmonary hemorrhage.
CONCLUSION :
The definition of EIS is yet obscure, thus more close observations for clinical course of CBSCT and pathophysiological research would be required.
Keywords: Early inflammatory syndrome, Engraftment syndrome, Cord blood stem cell transpantation