Korean J Hematol 2001; 36(1):
Published online March 31, 2001
© The Korean Society of Hematology
비 혈연간 조혈모세포이식을 위한 공여자 검색과정의 분석
김동욱, 민창기, 이석, 김광성, 임정혜, 조빈, 이종욱, 민우성, 김학기, 김춘추
가톨릭대학교 조혈모세포이식센터
Analysis of the Process for Unrelated Stem Cell Donor Search
Background: Between 1994 and 1999, 38,264 potential marrow donors typed for HLA-A, -B, and -DRB1 antigens had been recruited in the Korean registries. During the same period, 131 unrelated transplants have been carried out in Korea. In
present
study, the search procedure within the last two years for an unrelated donor at the Catholic University of Korea is analyzed.
Methods: The search for an unrelated donor for 287 patients was performed. Low resolutional HLA-A and -B typing was performed by serology and HLA-DRB1 typing was done by DNA-typing. We analyzed HLA match rate, the intervals between search
activation and transplant, coordination success rate, and the reasons of coordination failure. We also investigated the results of donor search process through the Japan Marrow Donor Program (JMDP) and Tzu-Chi Taiwan Marrow Donor Registry
(TCTMDR).
Results: At least one HLA-identical donor has been found for 54.7% of 287 patients in the first search using the Korean registries. As of the end of July 2000, 53 patients had received unrelated treanplants and the coordination success rate
was
33.8%. The average interval to transplant with the Korean registries was 128 days. The most common diagnosis in the patients who underwent transplantation was CML. Among 47 patients who registered in the JMDP, 25 patients found at least one
HLA-identical donor. Twelve of them were transplanted. The average time to transplants was 149 days. Since February 2000, we have registered 22 patients in the TCTMDR. Four of them had one HLA-matched donor and transplants are now in
progress.
Conclusion: The donor pool is rapidly expanding and the patients who receive unrelated transplant are also increasing in Korea. From these data, we realized that the international collaboration of Asian countries would be very important
for
facilitating unrelated transplants for patients who could not find suitable donor in their national registries.
Keywords Unrelated donor transplants; Korean registry; Donor center; Treansplantation center; KMDP; CHIB; JMDP; TCTMDR; HLA;
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Korean J Hematol 2001; 36(1): 18-24
Published online March 31, 2001
Copyright © The Korean Society of Hematology.
비 혈연간 조혈모세포이식을 위한 공여자 검색과정의 분석
김동욱, 민창기, 이석, 김광성, 임정혜, 조빈, 이종욱, 민우성, 김학기, 김춘추
가톨릭대학교 조혈모세포이식센터
Analysis of the Process for Unrelated Stem Cell Donor Search
Dong Wook Kim, Chang Ki Min, Seok Lee, Kwang Sung Kim, Jung Ae Lim, Bin Cho, Jong Wook Lee, Woo Sung Min, Hack Ki Kim, Chun Choo Kim
Catholic Hemopoietic Stem Cell Transplantation Center, The Catholic University of Korea, Seoul, Korea
Abstract
Background: Between 1994 and 1999, 38,264 potential marrow donors typed for HLA-A, -B, and -DRB1 antigens had been recruited in the Korean registries. During the same period, 131 unrelated transplants have been carried out in Korea. In
present
study, the search procedure within the last two years for an unrelated donor at the Catholic University of Korea is analyzed.
Methods: The search for an unrelated donor for 287 patients was performed. Low resolutional HLA-A and -B typing was performed by serology and HLA-DRB1 typing was done by DNA-typing. We analyzed HLA match rate, the intervals between search
activation and transplant, coordination success rate, and the reasons of coordination failure. We also investigated the results of donor search process through the Japan Marrow Donor Program (JMDP) and Tzu-Chi Taiwan Marrow Donor Registry
(TCTMDR).
Results: At least one HLA-identical donor has been found for 54.7% of 287 patients in the first search using the Korean registries. As of the end of July 2000, 53 patients had received unrelated treanplants and the coordination success rate
was
33.8%. The average interval to transplant with the Korean registries was 128 days. The most common diagnosis in the patients who underwent transplantation was CML. Among 47 patients who registered in the JMDP, 25 patients found at least one
HLA-identical donor. Twelve of them were transplanted. The average time to transplants was 149 days. Since February 2000, we have registered 22 patients in the TCTMDR. Four of them had one HLA-matched donor and transplants are now in
progress.
Conclusion: The donor pool is rapidly expanding and the patients who receive unrelated transplant are also increasing in Korea. From these data, we realized that the international collaboration of Asian countries would be very important
for
facilitating unrelated transplants for patients who could not find suitable donor in their national registries.
Keywords: Unrelated donor transplants, Korean registry, Donor center, Treansplantation center, KMDP, CHIB, JMDP, TCTMDR, HLA,
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