Korean J Hematol 1997; 32(2):
Published online June 30, 1997
© The Korean Society of Hematology
자가 면역성 갑상선 질환과 동반된 악성빈혈 1례
김동규, 양성현, 고경수, 이병두, 김성록, 백인기
인제대학교 의과대학 상계백병원 내과,
인제대학교 의과대학 임상병리과
A Case of Pernicious Anemia Associated with Autoimmune Thyroid Disease
Pernicious anemia is understood as an autoimmune disease and associated with various other autoimmune diseases, such as Graves‘ disease, primary hypothyroidism,
thyroiditis and vitiligo. We report a case of pernicious anemia associated with autoimmune thyroiditis.
A 40-year-old man was admitted to the Sanggye Paik Hospital due to general weakness, dyspnea on exertion and sore throat for 2 months. Eight years before admission, he had been treated with hyperthyroidism in other hospital. Examination revealed anemic conjunctivae, exophthalmos and- smooth and beefy tongue. Laboratory tests showed 6.2g/dL of hemoglobin, 16.7% of hematocrit, 7,970/μL of WBC, 152,000/μL of platelets and 116.3fL of MCV. Reticulocyte index was 0.3%. Peripheral blood smear showed macrocytic red blood cells and hypersegmented neutrophils. The level of vitamin Bla was 139.2pg/mL and folic acid was in normal range. The result of schilling test was abnormal. Anti-parietal cell antibody was positive. The results of thyroid function tests were compatible with hypothyroidism and anti-microsomal antibody was positive. TBII was 9.8U/L. Treatment with vitamin B l2 and thyroid hormone was started. Three months after treatment, he has been completely free of symptoms. Now he has been treated with thyroxine 0.2㎎ per day and adenosylcobalamine 1,000㎍ per 2 month.
Keywords Pernicious anemia; Autoimmune thyroid disease;
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Korean J Hematol 1997; 32(2): 292-296
Published online June 30, 1997
Copyright © The Korean Society of Hematology.
자가 면역성 갑상선 질환과 동반된 악성빈혈 1례
김동규, 양성현, 고경수, 이병두, 김성록, 백인기
인제대학교 의과대학 상계백병원 내과,
인제대학교 의과대학 임상병리과
A Case of Pernicious Anemia Associated with Autoimmune Thyroid Disease
Dong Kyu Kim, Sung Hyun Yang, Kyung Soo Ko, Byoung Doo Rhee, Sung Rok Kim, In Ki Paik
Department of Internal Medicine, Clinical Pathology, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea
Abstract
Pernicious anemia is understood as an autoimmune disease and associated with various other autoimmune diseases, such as Graves‘ disease, primary hypothyroidism,
thyroiditis and vitiligo. We report a case of pernicious anemia associated with autoimmune thyroiditis.
A 40-year-old man was admitted to the Sanggye Paik Hospital due to general weakness, dyspnea on exertion and sore throat for 2 months. Eight years before admission, he had been treated with hyperthyroidism in other hospital. Examination revealed anemic conjunctivae, exophthalmos and- smooth and beefy tongue. Laboratory tests showed 6.2g/dL of hemoglobin, 16.7% of hematocrit, 7,970/μL of WBC, 152,000/μL of platelets and 116.3fL of MCV. Reticulocyte index was 0.3%. Peripheral blood smear showed macrocytic red blood cells and hypersegmented neutrophils. The level of vitamin Bla was 139.2pg/mL and folic acid was in normal range. The result of schilling test was abnormal. Anti-parietal cell antibody was positive. The results of thyroid function tests were compatible with hypothyroidism and anti-microsomal antibody was positive. TBII was 9.8U/L. Treatment with vitamin B l2 and thyroid hormone was started. Three months after treatment, he has been completely free of symptoms. Now he has been treated with thyroxine 0.2㎎ per day and adenosylcobalamine 1,000㎍ per 2 month.
Keywords: Pernicious anemia, Autoimmune thyroid disease,
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