A Case of Cytomegalovirus Mononucleosis Detected by In Situ Hybridization

Jung Oh; Eun Jee Oh; Yong Goo Kim; Eun Jung Lee; Kyung Ja Han; Sang In Shim

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Korean J Hematol 1996; 31(1):

Published online March 31, 1996

동소보합결합법으로 발견된 거대세포바이러스성 단핵세포증 1례

오정, 오은지, 김용구, 이은정, 한경자, 심상인

가톨릭대학교 의과대학 임상병리학교실

A Case of Cytomegalovirus Mononucleosis Detected by In Situ Hybridization

Jung Oh, Eun Jee Oh, Yong Goo Kim, Eun Jung Lee, Kyung Ja Han, Sang In Shim

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Department of Clinical Pathology, Catholic University Medical College, Seoul, Korea

Abstract

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Abstract

Cytomegalovirus mononucleosis is associated with fever, negative heterophil antibody,
atypical lymphocytosis, lymphadenopathy, splenomegaly, and abnormal liver function test.
Recently, in situ hybridization has become a useful technique for rapid detection of viral
nucleic acids in formal in- fixed, paraffin-embedded tissue.
We experienced a case of cytomegalovirus mononucleosis in a 2-year-old female who
complained of high fever, cough and dyspnea. In situ hybridization of bone marrow
biopsy using biotinylated RNA probe to cytomegalovirus revealed positive result.

Keywords Cytomegalovirus, Mononucleosis, In situ hybridization