Korean J Hematol 1994; 29(2):
Published online June 30, 1994
© The Korean Society of Hematology
자연살세포성 백혈병 1례
임인수, 윤수영, 조윤정, 이갑노
고려대학교 의과대학 임상병리학교실
A Case of Natural Killer Cell Leukemia
Natural killer cell leukemia is a part of large granular Iymphocyte(LGL) leukemia, which has more rapidly progressive clinical course than other types of LGL leukemia. We experienced a 60 year-old female who had had hepatosplenomegaly and a fever for one month. On CBC, white blood cell count was 19.5×109/L, hemoglobin 95 g/L, platelet count 41×109/L. The LGLs made up 58% of peripheral leukocytes. Most of them were 15-20μm in diameter and had moderate amount of the cytoplasm with clumped nuclear chromatin. Several azurophilic granules were noted in their cytoplasm.
These cells were positive for acid phosphatase(AP) and negative for Periodic Acid Schiff(PAS), Sudan Black B(SBB), nonspecific esterase(NSE), tartrate-treated acid
phosphatase(TTAP) and terminal deoxynucleotidyl transferase(TdT).The immunophenotype of the cells was CD2+, CD3-, CD8-, CD16+, CD56+ that are characteristic of natural killer cells. The patient showed acute elevation in Iymphocyte
count up to 31,600/μL and expired on the 11th hospital day.
Keywords Leukemia; NK cell; Large granular Iymphocyte;
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Korean J Hematol 1994; 29(2): 229-234
Published online June 30, 1994
Copyright © The Korean Society of Hematology.
자연살세포성 백혈병 1례
임인수, 윤수영, 조윤정, 이갑노
고려대학교 의과대학 임상병리학교실
A Case of Natural Killer Cell Leukemia
I S Im, S Y Yoon, Y J Cho, K N Lee
Department of Clinical Pathology, College of Medicine, Korea University, Seoul, Korea
Abstract
Natural killer cell leukemia is a part of large granular Iymphocyte(LGL) leukemia, which has more rapidly progressive clinical course than other types of LGL leukemia. We experienced a 60 year-old female who had had hepatosplenomegaly and a fever for one month. On CBC, white blood cell count was 19.5×109/L, hemoglobin 95 g/L, platelet count 41×109/L. The LGLs made up 58% of peripheral leukocytes. Most of them were 15-20μm in diameter and had moderate amount of the cytoplasm with clumped nuclear chromatin. Several azurophilic granules were noted in their cytoplasm.
These cells were positive for acid phosphatase(AP) and negative for Periodic Acid Schiff(PAS), Sudan Black B(SBB), nonspecific esterase(NSE), tartrate-treated acid
phosphatase(TTAP) and terminal deoxynucleotidyl transferase(TdT).The immunophenotype of the cells was CD2+, CD3-, CD8-, CD16+, CD56+ that are characteristic of natural killer cells. The patient showed acute elevation in Iymphocyte
count up to 31,600/μL and expired on the 11th hospital day.
Keywords: Leukemia, NK cell, Large granular Iymphocyte,
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