Korean J Hematol 1994; 29(1):
Published online March 31, 1994
© The Korean Society of Hematology
철결핍성 및 만성질병성 빈혈에서 Zinc Protoporphyrin 의 측정
김도하, 서철원, 박선미, 김상욱, 김성배, 김상위, 안명주, 이규형, 이정신, 지현숙, 김상희
울산의대 서울중앙병원 내과학교실,
울산의대 서울중앙병원 임상병리과학교실
Blood Levels of Zinc Protoporphyrin in Anemias of Iron Deficiency and Chronic Disorders
Background: The protoporphyrinemia in iron deficiency is well recognized. Zinc protoporphyrin(ZPP) is considered to be a good screening parameter of iron deficient
erythropoiesis, surveying all steps of iron metabolism from iron uptake to its utilization. We investigated the relevance of ZPP to the detection of iron deficiency in iron
deficiency anemia(IDA) and derangements of iron metabolism in anemia of chronic disorders(ACD).
Methods: The blood levels of ZPP were measured quantitatively by hematofluorometer in 29 IDA and 17 ACD patients. Routine CBC, serum iron, ferritin, and total iron
binding capacity were also measured simultaneously. Correlation studies were performed between iron metabolism parameters and the levels of ZPP in each group.
Results:
1. ZPP was increased in 28 IDA patinet(89±52μg/dL). The ZPP was correlated with better Hb(r=-0.77, f=0.0001) than combination of ferritin and Hb.
2. ZPP was increased in 9 ACD patients(44.2±15.2μg/dL). There was no correlation between ZPP and Hb.
3. ZPP was increased more significantly in IDA than ACD(p=0.0004).
Conclusion: These results suggest that fluorometric determination of ZPP may be a useful method of screening and monitoring after treatment for IDA but the clinical
relevance of ZPP in ACD is not confirmed.
Keywords Zinc protoporphyrin; Hematofluorometer; Iron deficiency anemia; Anemia of chronic disorders;
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Korean J Hematol 1994; 29(1): 1-7
Published online March 31, 1994
Copyright © The Korean Society of Hematology.
철결핍성 및 만성질병성 빈혈에서 Zinc Protoporphyrin 의 측정
김도하, 서철원, 박선미, 김상욱, 김성배, 김상위, 안명주, 이규형, 이정신, 지현숙, 김상희
울산의대 서울중앙병원 내과학교실,
울산의대 서울중앙병원 임상병리과학교실
Blood Levels of Zinc Protoporphyrin in Anemias of Iron Deficiency and Chronic Disorders
Do Ha Kim, Cheolwon Suh, Sun Mi Park, Sang Wook Kim, Sung Bae Kim, Sang We Kim, Myung Ju Ann, Kyoo Hyung Lee, Jung Shin Lee, Hyun Sook Chi, Sang Hee Kim
Department of Medicine, Clinical Pathology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea
Abstract
Background: The protoporphyrinemia in iron deficiency is well recognized. Zinc protoporphyrin(ZPP) is considered to be a good screening parameter of iron deficient
erythropoiesis, surveying all steps of iron metabolism from iron uptake to its utilization. We investigated the relevance of ZPP to the detection of iron deficiency in iron
deficiency anemia(IDA) and derangements of iron metabolism in anemia of chronic disorders(ACD).
Methods: The blood levels of ZPP were measured quantitatively by hematofluorometer in 29 IDA and 17 ACD patients. Routine CBC, serum iron, ferritin, and total iron
binding capacity were also measured simultaneously. Correlation studies were performed between iron metabolism parameters and the levels of ZPP in each group.
Results:
1. ZPP was increased in 28 IDA patinet(89±52μg/dL). The ZPP was correlated with better Hb(r=-0.77, f=0.0001) than combination of ferritin and Hb.
2. ZPP was increased in 9 ACD patients(44.2±15.2μg/dL). There was no correlation between ZPP and Hb.
3. ZPP was increased more significantly in IDA than ACD(p=0.0004).
Conclusion: These results suggest that fluorometric determination of ZPP may be a useful method of screening and monitoring after treatment for IDA but the clinical
relevance of ZPP in ACD is not confirmed.
Keywords: Zinc protoporphyrin, Hematofluorometer, Iron deficiency anemia, Anemia of chronic disorders,
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