Korean J Hematol 1993; 28(1):
Published online March 31, 1993
© The Korean Society of Hematology
급성 림프구성 백혈병 환아에서 경시적으로 관찰한 말초혈 혈구 수가 치료 및 예후에 미치는 영향
김준희, 고동훈, 문대근, 국훈, 황태주
전남대학교 의과대학 소아과학교실
Effect of Peripheral Blood Cell Counts during Remission Induction and Maintenance Therapy on the Prognosis and Therapy of Childhood Acute Lymphoblastic Leukemia
Background: The prediction of remission induction or relapse of childhood acute lymphoblastic leukemia(ALL) by peripheral blood cell counts still remains to be clarified.
Methods: We analyzed the pattern of remission induction as well as relapse according to the blood cell counts during treatment of ALL. Fifty children with ALL were enrolled
from February 1983 to June 1991. The weekly measured white blood cells (WBC), absolute neutrophils (ANC), and platelets (PLT) counts during remission induction phase
as well as the monthly blood counts during maintenance therapy were studied to find out their prognostic importance on remission and relapse of the disease.
Results:
1) During remission induction phase, the initial WBC counts had no significant relationship, while the lower ANC at the 1st wk(p<0.01) as well as the higher PLT count at the 2nd wk(p<0.01) showed better chances to achieve complete remission.
2) The relapse rate was inversely correlated with the ANC at the 4th wk(p<0.05) of the remission induction, while it was not influenced by initial WBC counts and the
blood counts during maintenance therapy.
3) The relapse rate for the patients who had been followed over 2 years(N=38) showed no difference among the 3 mean WBC groups of 2,0, 3.0, and 5.0×109/㎣, and between the 2 ANC groups below and above 2.0×109/㎣ during maintenance.
4) The frequency of leukopenic episodes during maintenance therapy revealed no influence on the relapse rate.
Conclusion: Peripheral blood counts during treatment may play a role in predicting the remission induction as well as the relapse, though we need further larger cohort
study.
Keywords Acute lymphoblastic leukemia (ALL); Peripheral blood cell count; Relapse; Prognosis;
PDF
Standard view
Export citation
Share Article
Korean J Hematol 1993; 28(1): 81-88
Published online March 31, 1993
Copyright © The Korean Society of Hematology.
급성 림프구성 백혈병 환아에서 경시적으로 관찰한 말초혈 혈구 수가 치료 및 예후에 미치는 영향
김준희, 고동훈, 문대근, 국훈, 황태주
전남대학교 의과대학 소아과학교실
Effect of Peripheral Blood Cell Counts during Remission Induction and Maintenance Therapy on the Prognosis and Therapy of Childhood Acute Lymphoblastic Leukemia
Jun Hee Kim, Dong Hoon Ko, Dae Keun Moon, Hoon Kook, Tai Ju Hwang
Department of Pediatrics, School of Medicine, Chonnam University
Abstract
Background: The prediction of remission induction or relapse of childhood acute lymphoblastic leukemia(ALL) by peripheral blood cell counts still remains to be clarified.
Methods: We analyzed the pattern of remission induction as well as relapse according to the blood cell counts during treatment of ALL. Fifty children with ALL were enrolled
from February 1983 to June 1991. The weekly measured white blood cells (WBC), absolute neutrophils (ANC), and platelets (PLT) counts during remission induction phase
as well as the monthly blood counts during maintenance therapy were studied to find out their prognostic importance on remission and relapse of the disease.
Results:
1) During remission induction phase, the initial WBC counts had no significant relationship, while the lower ANC at the 1st wk(p<0.01) as well as the higher PLT count at the 2nd wk(p<0.01) showed better chances to achieve complete remission.
2) The relapse rate was inversely correlated with the ANC at the 4th wk(p<0.05) of the remission induction, while it was not influenced by initial WBC counts and the
blood counts during maintenance therapy.
3) The relapse rate for the patients who had been followed over 2 years(N=38) showed no difference among the 3 mean WBC groups of 2,0, 3.0, and 5.0×109/㎣, and between the 2 ANC groups below and above 2.0×109/㎣ during maintenance.
4) The frequency of leukopenic episodes during maintenance therapy revealed no influence on the relapse rate.
Conclusion: Peripheral blood counts during treatment may play a role in predicting the remission induction as well as the relapse, though we need further larger cohort
study.
Keywords: Acute lymphoblastic leukemia (ALL), Peripheral blood cell count, Relapse, Prognosis,
Previous Article
