Korean J Hematol 1993; 28(1):
Published online March 31, 1993
© The Korean Society of Hematology
성인 급성 림프구성 백혈병의 화학요법 효과
손창학, 구대식, 조기정, 이성근
인제대학교 의과대학 부산백병원 내과학교실
Efficacy of Therapy in the Adult Acute Lymphocytic Leukemia
Background: In acute lymphocytic leukemia (ALL) substantial progress of chemotherapy has been made in recent years. Although there is no standard regimen for
induction treatment in adult ALL, most regimens include prednisone, vincristine, daunorubicin and asparaginase. This study is to investigate the rate of complete
remission and survival of ALL treated with those agents.
Methods: Twenty-nine adults with acute lymphocytic leukemia were treated with three-or four-drug combination as induction followed by postremission therapy between
September 1987 and June 1992.
Results: Overall complete remission(CR) rate was 72% (21/29). Median duration of CR was 8.0 months(range, 2.0-48+). And in complete responders, 3-year relapse-free
survival (RFS) by Kaplan-Meier-method and relapse rate were 29.7% and 57% (12/21) respectively.
Contusion :
Improved therapy is needed by more intensified induction and consolidation therapy because of short duration of remission and high relapse rate, though CR rate is acceptable.
Keywords Efficacy of chemotherapy; Adult acute lymphocytic leukemia; Survival;
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Korean J Hematol 1993; 28(1): 31-38
Published online March 31, 1993
Copyright © The Korean Society of Hematology.
성인 급성 림프구성 백혈병의 화학요법 효과
손창학, 구대식, 조기정, 이성근
인제대학교 의과대학 부산백병원 내과학교실
Efficacy of Therapy in the Adult Acute Lymphocytic Leukemia
Chang Hak Sohn, Dae Sik Koo, Key Jung Cho, Sung Keun Lee
Department of Internal Medicine, Paik Hospital, College of Medicine, Inje University, Pusan, Korea
Abstract
Background: In acute lymphocytic leukemia (ALL) substantial progress of chemotherapy has been made in recent years. Although there is no standard regimen for
induction treatment in adult ALL, most regimens include prednisone, vincristine, daunorubicin and asparaginase. This study is to investigate the rate of complete
remission and survival of ALL treated with those agents.
Methods: Twenty-nine adults with acute lymphocytic leukemia were treated with three-or four-drug combination as induction followed by postremission therapy between
September 1987 and June 1992.
Results: Overall complete remission(CR) rate was 72% (21/29). Median duration of CR was 8.0 months(range, 2.0-48+). And in complete responders, 3-year relapse-free
survival (RFS) by Kaplan-Meier-method and relapse rate were 29.7% and 57% (12/21) respectively.
Contusion :
Improved therapy is needed by more intensified induction and consolidation therapy because of short duration of remission and high relapse rate, though CR rate is acceptable.
Keywords: Efficacy of chemotherapy, Adult acute lymphocytic leukemia, Survival,
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