Korean J Hematol 2005; 40(1):
Published online March 30, 2005
https://doi.org/10.5045/kjh.2005.40.1.28
© The Korean Society of Hematology
박세훈, 김민주, 김유진, 김정곤, 김태경, 양선미, 박세훈, 안태훈, 신익균, 방수미, 조은경, 신동복, 이재훈
가천의과대학교 길병원 내과학교실
Background:
The aims of this study were to find the incidence and clinical features of Heparin-induced thrombocytopenia (HIT) in acute coronary syndrome patients treated with unfractionated heparin.
Methods:
The medical records of 554 patients treated with unfractionated heparin (UFH) for their coronary artery diseases at the Gachon Medical School Gil Heart Center during 2002∼2003. were retrospectively reviewed. The gourp eligible group inclusion in this study was comprised of 338 patients with acute coronary syndrome
Results:
The median duration of UFH administration was 6 days, ranging from 1 to 22 days. Among the eligible patients, 40 (11.8%) received UFH for >96 hours, and developed thrombocytopenia, which involved a platelet count decrease to less than 100,000 per cubic millimeter or a 50% or greater decrease in the platelet count.
Conclusion:
Despith the limitations of retrospective analyses, the present study shows that thrombocytopenia is relatively common in acute coronary syndrome patients treated with UFH, but did not account for HIT associated complication, such as thrombosis. When clinicians recognize the development of HIT without a thrombocytopenia related disease, many will stop the use of heparin for its management.
Keywords Heparin, Thrombocytopenia, Coronary artery disease
Korean J Hematol 2005; 40(1): 28-33
Published online March 30, 2005 https://doi.org/10.5045/kjh.2005.40.1.28
Copyright © The Korean Society of Hematology.
박세훈, 김민주, 김유진, 김정곤, 김태경, 양선미, 박세훈, 안태훈, 신익균, 방수미, 조은경, 신동복, 이재훈
가천의과대학교 길병원 내과학교실
Se Hoon Park, Min Ju Kim, Yu Jin Kim, Jung Gon Kim, Tae Kyung Kim, Sun Mee Yang, Se Hoon Park, Tae Hoon Ahn, Eak Kyun Shin, Soo, Mee Bang, Eun Kyung Cho, Dong Bok Shin, Jae Hoon Lee
Department of Internal Medicine, Gachon Medical School Gil Medical Center, Gil Heart Center, Incheon, Korea
Background:
The aims of this study were to find the incidence and clinical features of Heparin-induced thrombocytopenia (HIT) in acute coronary syndrome patients treated with unfractionated heparin.
Methods:
The medical records of 554 patients treated with unfractionated heparin (UFH) for their coronary artery diseases at the Gachon Medical School Gil Heart Center during 2002∼2003. were retrospectively reviewed. The gourp eligible group inclusion in this study was comprised of 338 patients with acute coronary syndrome
Results:
The median duration of UFH administration was 6 days, ranging from 1 to 22 days. Among the eligible patients, 40 (11.8%) received UFH for >96 hours, and developed thrombocytopenia, which involved a platelet count decrease to less than 100,000 per cubic millimeter or a 50% or greater decrease in the platelet count.
Conclusion:
Despith the limitations of retrospective analyses, the present study shows that thrombocytopenia is relatively common in acute coronary syndrome patients treated with UFH, but did not account for HIT associated complication, such as thrombosis. When clinicians recognize the development of HIT without a thrombocytopenia related disease, many will stop the use of heparin for its management.
Keywords: Heparin, Thrombocytopenia, Coronary artery disease
Ka‑Won Kang
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