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Case Report

Korean J Hematol 2005; 40(4):

Published online December 30, 2005

https://doi.org/10.5045/kjh.2005.40.4.261

© The Korean Society of Hematology

골수종 세포의 간 침윤에 의한 비폐쇄성 황달을 보인 다발성 골수종 1예 - 조직 검사로 진단한 다발성 골수종의 간 침범 -

유미현, 김현우, 여영선, 임정우, 정우진, 한은미, 서철원, 김순배, 박수길, 이상구

울산대학교 의과대학 서울아산병원 내과학교실, 진단병리학교실

A Case of Multiple Myeloma Presenting as Non-obstructive Jaundice Due to Plasma Cell Infiltration of the Liver

Mi Hyun Yu, Hyun Woo Kim, Young Sun Yeo, Jeong Woo Lim, Woo Jin Jeong, Eun Mee Han, Chul Won Seo, Soon Bae Kim, Su Kil Park, Sang Koo Lee

Author Info. +

Departments of Internal Medicine, Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

Abstract

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Extraosseous manifestations are found in less than 5% of the patients with multiple myeloma. We reported here on a rare case of multiple myeloma presenting as non-obstructive jaundice due to diffuse plasma cell infiltration of the liver. A 70-year-old man was referred to our hospital because of general weakness, weight loss, jaundice, anemia and proteinuria. The laboratory studies showed: hemoglobin 8.5g/dL, calcium 10.3mg/dL, creatinine 1.3mg/dL, AST 41IU/L, ALT 26IU/L, alkaline phosphatase 304IU/L, total bilirubin 4.0mg/dL, direct bilirubin 2.3mg/dL and 24 hour urinary protein 1,120mg. The serologic tests for hepatitis B and C virus were negative. The abdominal CT scans were normal. The urinary protein studies revealed a M component of the lamda type light chain. The bone marrow biopsy showed atypical plasma cells, and the liver biopsy showed a diffuse sinusoidal infiltration of plasma cells.

Keywords Multiple myeloma, Plasma cell infiltration, Jaundice, Liver

Article

Case Report

Korean J Hematol 2005; 40(4): 261-265

Published online December 30, 2005 https://doi.org/10.5045/kjh.2005.40.4.261

Copyright © The Korean Society of Hematology.

골수종 세포의 간 침윤에 의한 비폐쇄성 황달을 보인 다발성 골수종 1예 - 조직 검사로 진단한 다발성 골수종의 간 침범 -

유미현, 김현우, 여영선, 임정우, 정우진, 한은미, 서철원, 김순배, 박수길, 이상구

울산대학교 의과대학 서울아산병원 내과학교실, 진단병리학교실

A Case of Multiple Myeloma Presenting as Non-obstructive Jaundice Due to Plasma Cell Infiltration of the Liver

Mi Hyun Yu, Hyun Woo Kim, Young Sun Yeo, Jeong Woo Lim, Woo Jin Jeong, Eun Mee Han, Chul Won Seo, Soon Bae Kim, Su Kil Park, Sang Koo Lee

Departments of Internal Medicine, Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

Abstract

Extraosseous manifestations are found in less than 5% of the patients with multiple myeloma. We reported here on a rare case of multiple myeloma presenting as non-obstructive jaundice due to diffuse plasma cell infiltration of the liver. A 70-year-old man was referred to our hospital because of general weakness, weight loss, jaundice, anemia and proteinuria. The laboratory studies showed: hemoglobin 8.5g/dL, calcium 10.3mg/dL, creatinine 1.3mg/dL, AST 41IU/L, ALT 26IU/L, alkaline phosphatase 304IU/L, total bilirubin 4.0mg/dL, direct bilirubin 2.3mg/dL and 24 hour urinary protein 1,120mg. The serologic tests for hepatitis B and C virus were negative. The abdominal CT scans were normal. The urinary protein studies revealed a M component of the lamda type light chain. The bone marrow biopsy showed atypical plasma cells, and the liver biopsy showed a diffuse sinusoidal infiltration of plasma cells.

Keywords: Multiple myeloma, Plasma cell infiltration, Jaundice, Liver

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