Korean J Hematol 2005; 40(3):
Published online September 30, 2005
https://doi.org/10.5045/kjh.2005.40.3.205
© The Korean Society of Hematology
주영돈, 이원식, 김정임, 양재욱, 김현웅, 박석국, 손창학
인제의대 부산백병원 혈액종양내과, 조혈모세포이식센터
Invasive aspergillosis (IA) of the paranasal sinuses is a rare infectious complication associated with allogeneic hematopoietic stem cell transplantation (HSCT). However, immunocompromised patients are particularly at risk of fulminant IA. The high risk of an invasive fungal infection (IFI) following allogeneic HSCT is due to several factors, including neutropenia before engraftment, disruption of mucosal barriers by various preparative regimens and the use of broad-spectrum antimicrobial agents, as well as the immunosuppressive effects of prophylaxis and treatment of GVHD. As the therapy for an IFI following allogeneic HSCT is often unsuccessful, the mortality rate is increased by 95%. Therefore,early diagnosis is important to overcome the high mortality of this destructive disease. In previous studies, high risks for the early onset of IA were demonstrated in patients with severe aplastic anemia (SAA), independent of the day of engraftment. Here, we report a case of invasive aspergillosis of the maxillary sinuses and orbit in a 50 years old man with SAA,who underwent an allogeneic HSCT from a HLA-matched sibling conditioned with Cytoxan/Fludara/ATG.
Keywords Maxillary sinus, Orbit, Aspergillosis, Severe aplastic anemia, Allogeneic hematopoietic stem cell transplantation
Korean J Hematol 2005; 40(3): 205-208
Published online September 30, 2005 https://doi.org/10.5045/kjh.2005.40.3.205
Copyright © The Korean Society of Hematology.
주영돈, 이원식, 김정임, 양재욱, 김현웅, 박석국, 손창학
인제의대 부산백병원 혈액종양내과, 조혈모세포이식센터
Young Don Joo, Won Sik Lee, Jung Lim Kim, Jae Wook Yang, Hyun Woong Kim, Seong Kook Park, Chang Hak Sohn
Departments of, Internal Medicine, Ophthalmology, Otorhinolaryngology, College of Medicine, Inje University, Busan, Korea
Invasive aspergillosis (IA) of the paranasal sinuses is a rare infectious complication associated with allogeneic hematopoietic stem cell transplantation (HSCT). However, immunocompromised patients are particularly at risk of fulminant IA. The high risk of an invasive fungal infection (IFI) following allogeneic HSCT is due to several factors, including neutropenia before engraftment, disruption of mucosal barriers by various preparative regimens and the use of broad-spectrum antimicrobial agents, as well as the immunosuppressive effects of prophylaxis and treatment of GVHD. As the therapy for an IFI following allogeneic HSCT is often unsuccessful, the mortality rate is increased by 95%. Therefore,early diagnosis is important to overcome the high mortality of this destructive disease. In previous studies, high risks for the early onset of IA were demonstrated in patients with severe aplastic anemia (SAA), independent of the day of engraftment. Here, we report a case of invasive aspergillosis of the maxillary sinuses and orbit in a 50 years old man with SAA,who underwent an allogeneic HSCT from a HLA-matched sibling conditioned with Cytoxan/Fludara/ATG.
Keywords: Maxillary sinus, Orbit, Aspergillosis, Severe aplastic anemia, Allogeneic hematopoietic stem cell transplantation
Jieun Uhm
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