Case Report
Korean J Hematol 2009; 44(2):
Published online June 30, 2009
https://doi.org/10.5045/kjh.2009.44.2.100
© The Korean Society of Hematology
만성골수성백혈병 만성기에서 급성기로 전환 시 동반된 암유전자 N-ras Gene의 돌연변이
송성헌 노영욱 안용우 김연재 변영상 최지영 황덕원 박병배 최정혜 김인순 김병국 이영열
한양대학교 의과대학 내과학교실,
서울대학교 의과대학 내과학교실
Mutation of the N-ras Gene in a Patient Suffering from the Blast Phase of Chronic Myelogenous Leukemia
The blast phase in chronic myelogenous leukemia (CML) is associated with mutation of several genes. It is well known that p53 gene mutation plays a key role in the myeloid or lymphoid blast phase of CML. But for the case of the N-ras gene, the association between N-ras mutations and the blast phase of CML is not yet known. We report here on a case of detecting N-ras point mutation without p53 mutation in a 64 year-old man who suffered from the lymphoblastic blast phase of CML. (Korean J Hematol 2009;44:100-103.)
Keywords Chronic myelogenous leukemia, Gene mutation, Blast phase, N-ras
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Case Report
Korean J Hematol 2009; 44(2): 100-103
Published online June 30, 2009 https://doi.org/10.5045/kjh.2009.44.2.100
Copyright © The Korean Society of Hematology.
만성골수성백혈병 만성기에서 급성기로 전환 시 동반된 암유전자 N-ras Gene의 돌연변이
송성헌 노영욱 안용우 김연재 변영상 최지영 황덕원 박병배 최정혜 김인순 김병국 이영열
한양대학교 의과대학 내과학교실,
서울대학교 의과대학 내과학교실
Mutation of the N-ras Gene in a Patient Suffering from the Blast Phase of Chronic Myelogenous Leukemia
Sung Heon Song, Young Wook Roh, Yong Woo Ahn, Yeon Jae Kim, Young Sang Byoun, Ji Young Choi, Deok Won Hwang, Byoung Bae Park, Jung Hye Choi, In Soon Kim, Byoung Kook Kim, Young Yiul Lee
Department of Internal Medicine, College of Medicine, Hanyang University, Seoul National University, Seoul, Korea
Abstract
The blast phase in chronic myelogenous leukemia (CML) is associated with mutation of several genes. It is well known that p53 gene mutation plays a key role in the myeloid or lymphoid blast phase of CML. But for the case of the N-ras gene, the association between N-ras mutations and the blast phase of CML is not yet known. We report here on a case of detecting N-ras point mutation without p53 mutation in a 64 year-old man who suffered from the lymphoblastic blast phase of CML. (Korean J Hematol 2009;44:100-103.)
Keywords: Chronic myelogenous leukemia, Gene mutation, Blast phase, N-ras
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