Korean J Hematol 2009; 44(1):
Published online March 30, 2009
https://doi.org/10.5045/kjh.2009.44.1.47
© The Korean Society of Hematology
이상민 권민정 강명주 이은주 이원식 손창학 이자영 이정녀 김혁 주영돈
인제대학교 의과대학
부산백병원 내과학교실, 진단검사의학과교실,
울산대학교 의과대학 울산대학교병원 내과학교실
Background: Autologous peripheral blood stem cell transplantation (PBSCT) has been used as a major treatment strateg for malignant lymphoproliferative disorder. The number of CD34 positive cells in the harvested product is a very important factor for achieving successful transplantation. We studied the factors that can predict the number of CD34 positive cells in the harvested product of multiple myeloma (MM) and Non-Hodgkin's lymphoma (NHL) patients after mobilizing them with chemotherapy plus G-CSF.
Methods: A total of 69 patients (MM 25 patients, NHL 44 patients) with malignant lymphoproliferative disorder had been mobilizedwith chemotherapy and granulocyte colony-stimulating growth factor from January, 2003 to July, 2008. We analyzed the clinical characteristics, the peripheral blood (PB) parameters and the number of CD34 positve cells in the PB and their correlation with the yield of PBPCs collected from the mobilized patients.
Results: The total number of leukapheresis sessions was 134 (mean: 1.94 session per patient), and the mean number of harvested CD34 positive cell per patient was 12.47×106/kg. The number of harvested CD34 positive cells was correlated with the patient's height, the number of peripheral blood hematopoietic progenitor cells (HPC) and the number of PB CD34 positive cells at the harvest (P<0.05). But the number of PB CD34 positive cell was the only significant factor for the quantity of harvested CD34 positive cells on the linear regression analysis (P<0.05). More than 23.7/ՌL PB CD34 positive cells were needed to harvest 3×106/kg CD34 positive cells, according to the ROC curve (P<0.05).
Conclusion: The number of PB CD34 positive cells (≥23.7/ՌL) at the harvest might be the predictor of harvesting more than 3×106/kg CD34 positive cell for autologous PBSCT in patients with malignant lymphoproliferative disorder.
Keywords CD34 positive cell, Mobilization, Harvest
Korean J Hematol 2009; 44(1): 47-52
Published online March 30, 2009 https://doi.org/10.5045/kjh.2009.44.1.47
Copyright © The Korean Society of Hematology.
이상민 권민정 강명주 이은주 이원식 손창학 이자영 이정녀 김혁 주영돈
인제대학교 의과대학
부산백병원 내과학교실, 진단검사의학과교실,
울산대학교 의과대학 울산대학교병원 내과학교실
Sang Min Lee, Min Jeong Kwon, Myung Joo Kang, Eun Joo Lee, Won Sik Lee, Chang Hak Sohn, Ja Young Lee, Jeong Nyeo Lee, Hawk Kim, Young Don Joo
Department of Internal Medicine and Labatory Medicine, Busan Paik Hospital, Inje University College of Medicine Busan
Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea
Background: Autologous peripheral blood stem cell transplantation (PBSCT) has been used as a major treatment strateg for malignant lymphoproliferative disorder. The number of CD34 positive cells in the harvested product is a very important factor for achieving successful transplantation. We studied the factors that can predict the number of CD34 positive cells in the harvested product of multiple myeloma (MM) and Non-Hodgkin's lymphoma (NHL) patients after mobilizing them with chemotherapy plus G-CSF.
Methods: A total of 69 patients (MM 25 patients, NHL 44 patients) with malignant lymphoproliferative disorder had been mobilizedwith chemotherapy and granulocyte colony-stimulating growth factor from January, 2003 to July, 2008. We analyzed the clinical characteristics, the peripheral blood (PB) parameters and the number of CD34 positve cells in the PB and their correlation with the yield of PBPCs collected from the mobilized patients.
Results: The total number of leukapheresis sessions was 134 (mean: 1.94 session per patient), and the mean number of harvested CD34 positive cell per patient was 12.47×106/kg. The number of harvested CD34 positive cells was correlated with the patient's height, the number of peripheral blood hematopoietic progenitor cells (HPC) and the number of PB CD34 positive cells at the harvest (P<0.05). But the number of PB CD34 positive cell was the only significant factor for the quantity of harvested CD34 positive cells on the linear regression analysis (P<0.05). More than 23.7/ՌL PB CD34 positive cells were needed to harvest 3×106/kg CD34 positive cells, according to the ROC curve (P<0.05).
Conclusion: The number of PB CD34 positive cells (≥23.7/ՌL) at the harvest might be the predictor of harvesting more than 3×106/kg CD34 positive cell for autologous PBSCT in patients with malignant lymphoproliferative disorder.
Keywords: CD34 positive cell, Mobilization, Harvest
Karin Zattar Cecyn, Eliza Y.S. Kimura, Dulce Marta S.M. Lima, Miyoko Yamamoto, José Orlando Bordin, and José Salvador R. de Oliveira
Blood Res 2018; 53(1): 61-70Jin Tae Jung, Woo Jin Sung, Yee Soo Chae, Kwang Woon Seo, Sung Won Park, Dong Seok Kwak, Jong Gwang Kim, Sang Kyun Sohn, Kyu Bo Lee, Hee Eun Kwon, Nan Young Lee, Jang Soo Suh
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