Multiple myeloma" />
Korean J Hematol 2008; 43(3):
Published online September 30, 2008
https://doi.org/10.5045/kjh.2008.43.3.194
© The Korean Society of Hematology
윤각원 송익찬 진선아 양영준 박남환 이효진 윤환중 김삼용 조덕연
충남대학교 의과대학 내과학교실
Central nervous system (CNS) myelomatosis, which is the presence of monoclonal plasma cells in the cerebrospinal fluid (CSF), is extremely rare. We report a case of CNS myelomatosis developed in a 45-year-old woman with multiple myeloma in complete response, which was achieved by allogeneic peripheral blood stem cell transplantation using a reduced-intensity conditioning regimen consisting of melphalan, fludarabine, and antithymocyte globulin. Two months after the transplant, she developed a moderate motor and sensory weakness in both lower extremities. Atypical plasma cells were found in the CSF, and immunofixation revealed monoclonal light chain in the CSF. She was given three courses of weekly intra-thecal chemotherapy consisting of methotrexate, cytarabine, and dexamethasone, which cleared the CSF. This case indicates that the allogeneic transplantation could not control CNS myelomatosis, despite successfully treating the bone marrow myeloma.
Keywords Multiple myeloma, CNS myelomatosis, Allogeneic stem cell transplantation, Intra-thecal chemotherapy
Korean J Hematol 2008; 43(3): 194-197
Published online September 30, 2008 https://doi.org/10.5045/kjh.2008.43.3.194
Copyright © The Korean Society of Hematology.
윤각원 송익찬 진선아 양영준 박남환 이효진 윤환중 김삼용 조덕연
충남대학교 의과대학 내과학교실
Gak Won Yun, Ik Chan Song, Seon Ah Jin, Young Joon Yang, Nam Hwan Park, Hyo Jin Lee, Hwan Jung Yun, Sam yong Kim, Deog Yeon Jo
Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Korea
Central nervous system (CNS) myelomatosis, which is the presence of monoclonal plasma cells in the cerebrospinal fluid (CSF), is extremely rare. We report a case of CNS myelomatosis developed in a 45-year-old woman with multiple myeloma in complete response, which was achieved by allogeneic peripheral blood stem cell transplantation using a reduced-intensity conditioning regimen consisting of melphalan, fludarabine, and antithymocyte globulin. Two months after the transplant, she developed a moderate motor and sensory weakness in both lower extremities. Atypical plasma cells were found in the CSF, and immunofixation revealed monoclonal light chain in the CSF. She was given three courses of weekly intra-thecal chemotherapy consisting of methotrexate, cytarabine, and dexamethasone, which cleared the CSF. This case indicates that the allogeneic transplantation could not control CNS myelomatosis, despite successfully treating the bone marrow myeloma.
Keywords: Multiple myeloma, CNS myelomatosis, Allogeneic stem cell transplantation, Intra-thecal chemotherapy
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