Korean J Hematol 2008; 43(1):
Published online March 30, 2008
https://doi.org/10.5045/kjh.2008.43.1.1
© The Korean Society of Hematology
이종욱
가톨릭대학교 의과대학 성모병원 혈액내과
Chronic graft-versus-host disease (GVHD) is the most frequent late complication after hematopoietic cell transplantation and has a major impact on the quality of life and survival. As the pathophysiology of GVHD is still incompletely understood, it has been difficult to design effective prophylactic regimens. However, prevention of acute GVHD appears to result in a lower incidence of chronic GVHD. The use of younger, non-allo-sensitized donors, preferentially of the same sex as the patient, and the use of stem cells other than G-CSF-mobilized peripheral blood stem cells, are associated with a decreased frequency of chronic GVHD. Further, the incorporation of thymoglobulin into the conditioning regimen has been demonstrated as beneficial to reduce chronic GVHD and delayed complications.
Keywords Chronic GVHD, Prevention, Hematopoietic cell transplantation
Korean J Hematol 2008; 43(1): 1-8
Published online March 30, 2008 https://doi.org/10.5045/kjh.2008.43.1.1
Copyright © The Korean Society of Hematology.
이종욱
가톨릭대학교 의과대학 성모병원 혈액내과
JongWook Lee
Division of Hematology, Department of Internal Medicine, Catholic Hematopoietic Stem Cell Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea
Chronic graft-versus-host disease (GVHD) is the most frequent late complication after hematopoietic cell transplantation and has a major impact on the quality of life and survival. As the pathophysiology of GVHD is still incompletely understood, it has been difficult to design effective prophylactic regimens. However, prevention of acute GVHD appears to result in a lower incidence of chronic GVHD. The use of younger, non-allo-sensitized donors, preferentially of the same sex as the patient, and the use of stem cells other than G-CSF-mobilized peripheral blood stem cells, are associated with a decreased frequency of chronic GVHD. Further, the incorporation of thymoglobulin into the conditioning regimen has been demonstrated as beneficial to reduce chronic GVHD and delayed complications.
Keywords: Chronic GVHD, Prevention, Hematopoietic cell transplantation
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