Korean J Hematol 2007; 42(3):
Published online September 30, 2007
https://doi.org/10.5045/kjh.2007.42.3.206
© The Korean Society of Hematology
배정준, 장여순, 김정윤, 임연정, 박현경, 한진영, 이영호
한양대학교 의과대학 소아과학교실,
동아대학교 의과대학 진단검사의학교실
Background:
We investigated the incidence of cytogenetic abnormalities as well as the correlation of the cytogenetic abnormalities and clinical outcomes based on the prognostic factors of the Children Cancer Group (CCG) in children with acute leukemia.
Methods:
We retrospectively reviewed the cytogenetic studies and clinical data from 99 children that were diagnosed with acute leukemia and treated with CCG regimens in two institutions. A conventional cytogenetic analysis was performed.
Results:
The incidence of cytogenetic abnormalities was 51 (51.5%) in 99 patients, and 27 (39.7%) in acute lymphoblastic leukemia (ALL) patients and 24 (77.4%) in acute myelogenous leukemia (AML) patients. The most frequent cytogenetic abnormality was hyperdiploidy and t(8:21) in the ALL and AML patients, respectively. The overall survival rate (OS)/disease free survival rate (DFS) of the ALL patients was 74.0%/73.9%. The OS/DFS of the standard risk group (88.8%/85.2%) was significantly higher than that of the high-risk group (49.4%/39.3%) in the ALL patients (P=0.0005/P<0.0001). There was no significant difference in the survival rates according to the type of cytogenetic abnormalities among the ALL patients for the standard/high risk groups, based on the CCG prognostic factors. The OS/DFS of the AML patients were 43.4% and 41.7%, respectively, without significant differences of the survival rates according to the type of chromosomal abnormalities.
Conclusion:
There were significant differences of OS/DFS based on the risk groups in ALL patients when evaluated with the CCG prognostic factors (standard/high) and chromosomal abnormalities (good/ poor), respectively. However, there was no significant correlation between type of cytogenetic abnormalities and clinical outcomes based on the CCG prognostic factors in children with ALL as well as with AML.
Keywords Diffuse large B-cell lymphoma, Bcl-2, Bcl-6, CD10, IRF-4, Germinal center subgroup
Korean J Hematol 2007; 42(3): 206-215
Published online September 30, 2007 https://doi.org/10.5045/kjh.2007.42.3.206
Copyright © The Korean Society of Hematology.
배정준, 장여순, 김정윤, 임연정, 박현경, 한진영, 이영호
한양대학교 의과대학 소아과학교실,
동아대학교 의과대학 진단검사의학교실
Jung Jun Bae, Yeo Soon Jang, Jung Yun Kim, Yeon Jung Lim, Hyun Kyung Park, Jin Yeong Han, Young Ho Lee
Department of Pediatrics, Hanyang University College of Medicine, Seoul
Department of Laboratory Medicine, Dong, A University College of Medicine, Busan, Korea
Background:
We investigated the incidence of cytogenetic abnormalities as well as the correlation of the cytogenetic abnormalities and clinical outcomes based on the prognostic factors of the Children Cancer Group (CCG) in children with acute leukemia.
Methods:
We retrospectively reviewed the cytogenetic studies and clinical data from 99 children that were diagnosed with acute leukemia and treated with CCG regimens in two institutions. A conventional cytogenetic analysis was performed.
Results:
The incidence of cytogenetic abnormalities was 51 (51.5%) in 99 patients, and 27 (39.7%) in acute lymphoblastic leukemia (ALL) patients and 24 (77.4%) in acute myelogenous leukemia (AML) patients. The most frequent cytogenetic abnormality was hyperdiploidy and t(8:21) in the ALL and AML patients, respectively. The overall survival rate (OS)/disease free survival rate (DFS) of the ALL patients was 74.0%/73.9%. The OS/DFS of the standard risk group (88.8%/85.2%) was significantly higher than that of the high-risk group (49.4%/39.3%) in the ALL patients (P=0.0005/P<0.0001). There was no significant difference in the survival rates according to the type of cytogenetic abnormalities among the ALL patients for the standard/high risk groups, based on the CCG prognostic factors. The OS/DFS of the AML patients were 43.4% and 41.7%, respectively, without significant differences of the survival rates according to the type of chromosomal abnormalities.
Conclusion:
There were significant differences of OS/DFS based on the risk groups in ALL patients when evaluated with the CCG prognostic factors (standard/high) and chromosomal abnormalities (good/ poor), respectively. However, there was no significant correlation between type of cytogenetic abnormalities and clinical outcomes based on the CCG prognostic factors in children with ALL as well as with AML.
Keywords: Diffuse large B-cell lymphoma, Bcl-2, Bcl-6, CD10, IRF-4, Germinal center subgroup
Samyong Kim, Sang, Eun Park, Su, Jin Park, Nam, Suk Park, Jae, Min Chun, Nam, Whan Park, Yung, Jun Yang, Kak, Won Yun, Hwan, Jung Yun, Jin, Man Kim, Deogyeon Jo, Samyong Kim,
Korean J Hematol 2005; 40(1): 15-22Xiaobo Liu, Yanliang Bai, Ying Liu, Weiya Li, Yabin Cui, Jinhui Xu, Xingjun Xiao, Xiaona Niu, Kai Sun
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