Korean J Hematol 2007; 42(4):
Published online December 30, 2007
https://doi.org/10.5045/kjh.2007.42.4.423
© The Korean Society of Hematology
이동미, 오성용, 윤현아, 김성현, 권혁찬, 이수철, 김효진
동아대학 의과대학 내과학교실
Side effects of rituximab are mild in most cases, but there have been a few cases of severe pulmonary toxicity reported in elderly patients. Here we report a case of interstitial pneumonitis following rituximab treatment in a young patient. A 35-year-old woman with diffuse large B-cell lymphoma was admitted complaining of dry cough and dyspnea without fever after the 3 treatments with rituximab-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy. Her chest CT with high- resolution CT scanning confirmed the presence of bilateral diffuse ground-glass opacities. The analysis of arterial blood gases indicated hypoxemia. The pulmonary function testing showed a restrictive pattern. There were no other findings suggesting an infection. The findings were compatible with a rituximab-induced interstitial pneumonitis. After the patient was treated with prednisolone, the symptoms resolved. Cases with rituximab-induced interstitial pneumonitis develop principally in elderly patients. However, the condition also can occur in young patients.
Keywords Rituximab, Interstitial pneumonitis, Young patient, Diffuse large B-cell lymphoma
Korean J Hematol 2007; 42(4): 423-427
Published online December 30, 2007 https://doi.org/10.5045/kjh.2007.42.4.423
Copyright © The Korean Society of Hematology.
이동미, 오성용, 윤현아, 김성현, 권혁찬, 이수철, 김효진
동아대학 의과대학 내과학교실
Dong Mee Lee, Sung Yong Oh, Hyun Ah Yoon, Suee Lee, Sung Hyun Kim, Hyuk Chan Kwon, Soo, Keol Lee, Hyo, Jin Kim
Department of Internal Medicine, Dong, A University College of Medicine, Busan, Korea
Side effects of rituximab are mild in most cases, but there have been a few cases of severe pulmonary toxicity reported in elderly patients. Here we report a case of interstitial pneumonitis following rituximab treatment in a young patient. A 35-year-old woman with diffuse large B-cell lymphoma was admitted complaining of dry cough and dyspnea without fever after the 3 treatments with rituximab-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy. Her chest CT with high- resolution CT scanning confirmed the presence of bilateral diffuse ground-glass opacities. The analysis of arterial blood gases indicated hypoxemia. The pulmonary function testing showed a restrictive pattern. There were no other findings suggesting an infection. The findings were compatible with a rituximab-induced interstitial pneumonitis. After the patient was treated with prednisolone, the symptoms resolved. Cases with rituximab-induced interstitial pneumonitis develop principally in elderly patients. However, the condition also can occur in young patients.
Keywords: Rituximab, Interstitial pneumonitis, Young patient, Diffuse large B-cell lymphoma
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