Korean J Hematol 2003; 38(2):
Published online June 30, 2003
© The Korean Society of Hematology
동종골수이식 후 고립성슬관절재발이 발생한 급성림프구성백혈병 환자에서 공여자림프구주입술의 효과
김주상, 이석, 김유진, 임지향, 김명신, 김민수, 이승우, 박윤희, 김희제, 김동욱, 이종욱, 민우성, 강창석, 김춘추
가톨릭대학교 의과대학 내과학교실,
가톨릭대학교 의과대학 조혈모세포이식센터,
가톨릭대학교 의과대학 임상병리학교실
Effect of Donor Lymphocyte Infusion for a Patient with Isolated Knee Joint Relapse of Acute Lymphoblastic Leukemia after Allogeneic Bone Marrow Transplantation
Isolated extramedullary relapse of acute lymphoblastic leukemia (ALL) after allogeneic bone marrow transplantation (BMT) in the absence of marrow involvement is a rare event, and the mechanisms underlying the selective involvement of extramedullary sites remain undefined. These might be due to relapse in sanctuary sites where the leukemic cells are resistant to preparative regimen, or a stronger graft-versus-leukemia effect in the marrow as compared with peripheral tissues. We report an adult ALL patient who experienced isolated extramedullary relapse in the right pretibial soft tissue and knee joint 42 months after allogeneic BMT. He was treated with localized radiotherapy followed by systemic chemotherapy and donor lymphocyte infusion. After treatment, he is currently well with no evidence of leukemia recurrence for 12 months.
Keywords Isolated extramedullary relapse; Knee joint; Acute lymphoblastic leukemia; Allogeneic bone marrow transplantation; Donor lymphocyte infusion;
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Korean J Hematol 2003; 38(2): 131-135
Published online June 30, 2003
Copyright © The Korean Society of Hematology.
동종골수이식 후 고립성슬관절재발이 발생한 급성림프구성백혈병 환자에서 공여자림프구주입술의 효과
김주상, 이석, 김유진, 임지향, 김명신, 김민수, 이승우, 박윤희, 김희제, 김동욱, 이종욱, 민우성, 강창석, 김춘추
가톨릭대학교 의과대학 내과학교실,
가톨릭대학교 의과대학 조혈모세포이식센터,
가톨릭대학교 의과대학 임상병리학교실
Effect of Donor Lymphocyte Infusion for a Patient with Isolated Knee Joint Relapse of Acute Lymphoblastic Leukemia after Allogeneic Bone Marrow Transplantation
Ju Sang Kim, Seok Lee, Yoo Jin Kim, Ji Hyang Lim, Myung Shin Kim, Min Soo Kim, Seung Woo Lee, Yoon Hee Park, Hee Je Kim, Dong Wook Kim, Jong Wook Lee, Woo Sung Min, Chang Suk Kang, Chun Choo Kim
Department of Internal Medicine,Catholic Hematopoietic Stem Cell Transplantation Center, Clinical Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea
Abstract
Isolated extramedullary relapse of acute lymphoblastic leukemia (ALL) after allogeneic bone marrow transplantation (BMT) in the absence of marrow involvement is a rare event, and the mechanisms underlying the selective involvement of extramedullary sites remain undefined. These might be due to relapse in sanctuary sites where the leukemic cells are resistant to preparative regimen, or a stronger graft-versus-leukemia effect in the marrow as compared with peripheral tissues. We report an adult ALL patient who experienced isolated extramedullary relapse in the right pretibial soft tissue and knee joint 42 months after allogeneic BMT. He was treated with localized radiotherapy followed by systemic chemotherapy and donor lymphocyte infusion. After treatment, he is currently well with no evidence of leukemia recurrence for 12 months.
Keywords: Isolated extramedullary relapse, Knee joint, Acute lymphoblastic leukemia, Allogeneic bone marrow transplantation, Donor lymphocyte infusion,
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