Korean J Hematol 2002; 37(3):
Published online September 30, 2002
© The Korean Society of Hematology
소아 B세포계 급성림프구성백혈병에서의 TEL/AML1 재배열 분석
최수진, 지현숙, 서을주, 박찬정, 서종진, 김태형, 문형남
울산의대 서울아산병원 진단검사의학과,
울산의대 서울아산병원 소아과
TEL/AML1 Fusion Transcripts in Childhood B-Lineage Acute Lymphoblastic Leukemia
Background : The t(12;21)(p 13;q22), which fuses the TEL gene on chromosome 12p13 and the AML1 gene on chromosome 21q22, is observed in approximately 20~25% of childhood B-lineage acute lymphoblastic leukemia(ALL) cases and is associated with a favorable outcome. A retrospective study was conducted to investigate the frequency of TEL/AML1 fusion in the patients diagnosed as childhood B-precursor ALL.
Method: Because of the low detection rate by routine karyotypic analysis, we studied 54 children with B-lineage ALL using the fluorescence in situ hybridization (FISH) analysis.
Results: Reuslts of this analysis demonstrated a 9.3% frequency of TEL/AML1 fusion, relatively lower than Japanese, Taiwanese and Caucasian children. All five patients with TEL/AML1 fusion showed CD10 positivity and predominance of male patients(4:1). Two cases of TEL/AML1 positive groups expressedthe myeloid antigens, but no significance was noted (p>0.05). In TEL/AML1 positive groups, the leukemia was developed between 4 and 5 years old age (favorable age) and showed low initial leukocyte
counts (<50,000/㎕).
Conclusion: Although these findings combined with earlier reports indicated that TEL/AML1 fusion was frequent genetic abnormality in childhood ALL, relatively low frequency in Korean patients suggested the existence ofgeographic or racial variations in the genotype of ALL.
Keywords Childhood; B-lineage ALL; TEL/AML1 fusion;
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Korean J Hematol 2002; 37(3): 169-176
Published online September 30, 2002
Copyright © The Korean Society of Hematology.
소아 B세포계 급성림프구성백혈병에서의 TEL/AML1 재배열 분석
최수진, 지현숙, 서을주, 박찬정, 서종진, 김태형, 문형남
울산의대 서울아산병원 진단검사의학과,
울산의대 서울아산병원 소아과
TEL/AML1 Fusion Transcripts in Childhood B-Lineage Acute Lymphoblastic Leukemia
Soo Jin Choi, Hyun Sook Chi, Chan Jeoung Park, Eul Zu Seo, Jong Jin Seo, Thad Ghim, Hyung Nam Moon
Department of Laboratory Medicine, Pediatrics, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
Abstract
Background : The t(12;21)(p 13;q22), which fuses the TEL gene on chromosome 12p13 and the AML1 gene on chromosome 21q22, is observed in approximately 20~25% of childhood B-lineage acute lymphoblastic leukemia(ALL) cases and is associated with a favorable outcome. A retrospective study was conducted to investigate the frequency of TEL/AML1 fusion in the patients diagnosed as childhood B-precursor ALL.
Method: Because of the low detection rate by routine karyotypic analysis, we studied 54 children with B-lineage ALL using the fluorescence in situ hybridization (FISH) analysis.
Results: Reuslts of this analysis demonstrated a 9.3% frequency of TEL/AML1 fusion, relatively lower than Japanese, Taiwanese and Caucasian children. All five patients with TEL/AML1 fusion showed CD10 positivity and predominance of male patients(4:1). Two cases of TEL/AML1 positive groups expressedthe myeloid antigens, but no significance was noted (p>0.05). In TEL/AML1 positive groups, the leukemia was developed between 4 and 5 years old age (favorable age) and showed low initial leukocyte
counts (<50,000/㎕).
Conclusion: Although these findings combined with earlier reports indicated that TEL/AML1 fusion was frequent genetic abnormality in childhood ALL, relatively low frequency in Korean patients suggested the existence ofgeographic or racial variations in the genotype of ALL.
Keywords: Childhood, B-lineage ALL, TEL/AML1 fusion,
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