Korean J Hematol 1999; 34(1):
Published online March 31, 1999
© The Korean Society of Hematology
13번 상염색체를 동반한 급성 미분화성 백혈병 1례
김은진, 전동석, 김재룡, 최귀전, 하정숙, 권기영
계명대학교 의과대학 임상병리학교실,
계명대학교 의과대학 내과학교실
A Case of Acute Undifferentiated Leukemia with Trisomy 13
The diagnosis of acute undifferentiated leukemia is made when the leukemic cells cannot be classified using morphologic and cytochemical analyses, and do not express
myeloid or lymphoid antigens. Trisomy 13 is a rare primary chromosomal abnormality in acute leukemia and associated with lineage inconsistency and poor prognosis. We report
a rare case of acute undifferentiated leuksmia showing negativity in periodic acid-Schiff(PAS) and myeloperoxidase(MPO) without any lineage-specific cell suface marker expression and having trisomy 13. The patient was a 72-ysar-old male who visited our hospital becauss of anemia and general weakness. On examination, leukocytosis with proliferated blasts(76%) in peripheral blood was noted. Bone marrow aspirate showed blast proliferation(74%) tilth morphologically hand-mirror type. The blast expressed CD34(96%) and HLA-DR(76%) in immunophenotyping. Cytogsnetic
study of bone marrow cells showed 46,XY,+13,-21[15]/46,XY[5]. Induction chemotherapy was failed and differentiation to monocytic series was noted.
Keywords Acute undiffersntiated leukemia, Trisomy 13, CD34, HLA-DR
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Korean J Hematol 1999; 34(1): 148-152
Published online March 31, 1999
Copyright © The Korean Society of Hematology.
13번 상염색체를 동반한 급성 미분화성 백혈병 1례
김은진, 전동석, 김재룡, 최귀전, 하정숙, 권기영
계명대학교 의과대학 임상병리학교실,
계명대학교 의과대학 내과학교실
A Case of Acute Undifferentiated Leukemia with Trisomy 13
Eun Jin Kim, Dong Seok Jeon, Jae Ryong Kim, Gui Jeon Choi, Jung Suk Ha, Ki Young Kwon
Department of Clinical Pathology, Internal Medicine, College of Medicine, Keimyung University, Taegu, Korea
Abstract
The diagnosis of acute undifferentiated leukemia is made when the leukemic cells cannot be classified using morphologic and cytochemical analyses, and do not express
myeloid or lymphoid antigens. Trisomy 13 is a rare primary chromosomal abnormality in acute leukemia and associated with lineage inconsistency and poor prognosis. We report
a rare case of acute undifferentiated leuksmia showing negativity in periodic acid-Schiff(PAS) and myeloperoxidase(MPO) without any lineage-specific cell suface marker expression and having trisomy 13. The patient was a 72-ysar-old male who visited our hospital becauss of anemia and general weakness. On examination, leukocytosis with proliferated blasts(76%) in peripheral blood was noted. Bone marrow aspirate showed blast proliferation(74%) tilth morphologically hand-mirror type. The blast expressed CD34(96%) and HLA-DR(76%) in immunophenotyping. Cytogsnetic
study of bone marrow cells showed 46,XY,+13,-21[15]/46,XY[5]. Induction chemotherapy was failed and differentiation to monocytic series was noted.
Keywords: Acute undiffersntiated leukemia, Trisomy 13, CD34, HLA-DR
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