Korean J Hematol 1999; 34(1):
Published online March 31, 1999
© The Korean Society of Hematology
김길영, 유철주, 양창현, 박송희, 박세명, 조현상, 신전수, 김세종, 김문규, 김황민
연세대학교 의과대학 소아과학교실,
연세대학교 의과대학 미생물학교실,
아주대학교 의과대학 소아과학교실,
연세대학교 원주의과대학 소아과학교실
Background: Genetic susceptibility to a variety of disease has bssn shown and it has recently been suggested that aplastic anemia is more common in adults who are HIA-
DR2+than in the general population.
Methods: To investigate whether certain HLA-DR gene is more common in children with aplastic anemia and HLA-DR2+ gene is associated with susceptibility to cyclosporine A(CyA), we analyzed the results of HLA-DR typing in 37 children with aplastic anemia with sequence specific oligonucleotide probe(SSOP) method.
Results: Eight patients were DR2+, and there was no more common than the normal population. All of the 8 patients wlth DR2+ were DRB1*1501+ with high resolution HLA
typing. Of the 8 patients with DRB1*1501+, 3 patients were treated with CyA alone(2 patients) or CyA plus ATG(1 patient), 2 patients were treated with ATG(1 patient) or
ALG alone(1 patient). Patients treatsd with CyA only or CyA plus ATG had either a complete(1 patient) or partial(2 patients) response and patients treated ATG or ALG
alone had no response.
Conclusion: Although incidence of HLA-DR2 was not significantly higher in children with aplastic anemia then normal population, response rate to CyA was significantly
high in the DR2+ patients.
Keywords Aplastic anemia, HLA-DR, Immunosuppresive therapy
Korean J Hematol 1999; 34(1): 36-42
Published online March 31, 1999
Copyright © The Korean Society of Hematology.
김길영, 유철주, 양창현, 박송희, 박세명, 조현상, 신전수, 김세종, 김문규, 김황민
연세대학교 의과대학 소아과학교실,
연세대학교 의과대학 미생물학교실,
아주대학교 의과대학 소아과학교실,
연세대학교 원주의과대학 소아과학교실
Kir Young Kim, Chuhl Joo Lyu, Chang Hyun Yang, Song Hee Park, Sae Myung Park, Hyun Sang Cho, Jeon Soo Shin, Se Jong Kim, Moon Kyu Kim, Hwang Min Kim
Department of Pediatrics, College of Medicine, Microbiology, Yonsei University, Seoul, Korea
Department of Pediatrics, College of Medicine, Hallym University, Korea
Department of Pediatrics, College of Medicine, Ajou University, Korea
Department of Pediatrics, College of Medicine, ,Yonsei University Wonnju College of Medicine, Korea
Background: Genetic susceptibility to a variety of disease has bssn shown and it has recently been suggested that aplastic anemia is more common in adults who are HIA-
DR2+than in the general population.
Methods: To investigate whether certain HLA-DR gene is more common in children with aplastic anemia and HLA-DR2+ gene is associated with susceptibility to cyclosporine A(CyA), we analyzed the results of HLA-DR typing in 37 children with aplastic anemia with sequence specific oligonucleotide probe(SSOP) method.
Results: Eight patients were DR2+, and there was no more common than the normal population. All of the 8 patients wlth DR2+ were DRB1*1501+ with high resolution HLA
typing. Of the 8 patients with DRB1*1501+, 3 patients were treated with CyA alone(2 patients) or CyA plus ATG(1 patient), 2 patients were treated with ATG(1 patient) or
ALG alone(1 patient). Patients treatsd with CyA only or CyA plus ATG had either a complete(1 patient) or partial(2 patients) response and patients treated ATG or ALG
alone had no response.
Conclusion: Although incidence of HLA-DR2 was not significantly higher in children with aplastic anemia then normal population, response rate to CyA was significantly
high in the DR2+ patients.
Keywords: Aplastic anemia, HLA-DR, Immunosuppresive therapy
Arihant Jain, Aditya Jandial, Thenmozhi Mani, Kamal Kishore, Charanpreet Singh, Deepesh Lad, Gaurav Prakash, Alka Khadwal, Reena Das, Neelam Varma, Subhash Varma and Pankaj Malhotra
Blood Res 2024; 59():Saurabh Shukla, Anil Kumar Tripathi, Shailendra Prasad Verma, Nidhi Awasthi
Blood Res 2020; 55(4): 193-199Chul Won Choi, Jun Ho Jang, Jin Seok Kim, Deog-Yeon Jo, Je-Hwan Lee, Sung-Hyun Kim, Yeo-Kyeoung Kim, Jong-Ho Won, Joo Seop Chung, Hawk Kim, Jae Hoon Lee, Min Kyoung Kim, Hyeon-Seok Eom, Shin Young Hyun, Jeong-A Kim, and Jong Wook Lee
Blood Res 2017; 52(3): 207-211