A Case of Chronic Neutrophilic Leukemia with Multiple Myeloma

Kwang Hyeun Kim; One Young Kim; Cheol Hyeon Jo; Seung Oeuk Lee; Bong Han Yoon; Myung Weon Kang; Yeun Keun Lim; Hyang Sun Yeu; Meung Hee Lee

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Korean J Hematol 1998; 33(3):

Published online September 30, 1998

다발성 골수종과 동반된 만성호중구성 백혈병 1례

김광현, 김원영, 조철현, 이승욱, 윤봉한, 강명원, 임연근, 여향순, 이명희

광주기독병원 내과,
광주기독병원 임상병리과

A Case of Chronic Neutrophilic Leukemia with Multiple Myeloma

Kwang Hyeun Kim, One Young Kim, Cheol Hyeon Jo, Seung Oeuk Lee, Bong Han Yoon, Myung Weon Kang, Yeun Keun Lim, Hyang Sun Yeu, Meung Hee Lee

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Department of Internal Medicine, Clinical Pathology, Kwang Ju Christian Hospital, Kwang Ju, Korea

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Abstract

Chronic neutrophilic leukemia(CNL) is a rare disorder characterized by persistent neutrophilia of mature cell type without evidence of infection, hepatosplenomegaly,
elevated neutrophil alkaline phosphatase score and the absence of Philadelphia chromosome
We report a typical case of CNL with multiple myeloma(IgG-λ type) in 68 years old female. Many neutrophils had toxic granule and vacuole. The peripheral blood smear showed neutrophlic leukocytosis(50,940/μL, neutrophil 94%) with rare immature form. The cytogenetic study showed normal karyotype without Philadelphia chromosome. She was diagnosed as multiple myeloma with paraproteinemia, lytic bone lesion of skull, and immature plasma cells in bone marrow.

Keywords Chronic neutrophilic leukemia; Multiple myeloma;